P-16 UNLOCKING S-PINDOLOL'S POTENTIAL FOR MASLD: BENEFICIAL EFFECTS ON MUSCLE MASS AND FUNCTION AND LIVER HISTOLOGY IN WESTERN- DIET FED MICE
Bibliographic record
Abstract
Conflict of interest: No Introduction and Objectives: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is linked to sarcopenia, which worsens disease's prognosis. The complex liver-muscle crosstalk opens the possibility that improvements in muscle quantity and quality may be directly beneficial for MASLD. This study investigates the effects of s-pindolol, a beta-blocker known for its anabolic properties, on both muscle mass and function as well as on MASLD progression in mice. Patients / Materials and Methods: Male C57BL6 mice were subjected to a western diet (WD) for 20 weeks to induce MASLD and then mice were randomly grouped and treated with 3 mg/kg s-pindolol twice a week or left untreated. Assessments included grip and isolated muscle strength, body composition via bioimpedance spectroscopy, Abdominal MRI, liver histology, serum analyses and gene expression profiling. Results and Discussion: S-pindolol reduced liver steatosis and inflammation and was associated with lower levels of MCP-1, IL-10, TGF-β, and ACACA (Acetyl-CoA Carboxylase Alpha). S-pindolol also counteracted IGF-1 serum levels reduction seen in WD-fed mice. In addition, S-pindolol treatment led to an increase in muscle mass as confirmed by bioimpedance spectroscopy and MRI techniques. While exercise performance remained unchanged, grip strength improved together with a reduction in myosteatosis suggesting enhanced muscle quality. This was supported by an increase in muscle fiber diameter, indicating muscular hypertrophy independent of exercise. Conclusions: S-pindolol treatment ameliorates MASLD and enhances muscle quality in WD-fed mice. It may be hypothesized that s-pindolol's positive effects on muscle mass and function could play a role in its beneficial effects on MASLD through improvement of secretion of various salutary myokines. The present data underscore S-pindolol's therapeutic potential in MASLD.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".