Regulation of Secondary Metabolite Pathways in <i>Ganoderma lucidum</i> under Environmental Stress
Bibliographic record
Abstract
This study explores the regulatory mechanisms of secondary metabolic pathways, particularly the biosynthesis of ganoderic acid (GA), in Ganoderma lucidum under various environmental stress conditions.The research identified several key environmental factors influencing GA biosynthesis, including water stress, heat stress, and nitrogen limitation.Water stress was found to increase intracellular reactive oxygen species (ROS) levels and GA content, mediated by the interaction between aquaporin (GlAQP) and NADPH oxidase (NOX).Heat stress was shown to inhibit mycelium growth and induce GA biosynthesis through increased cytosolic Ca 2+ concentration and membrane fluidity.Additionally, the mitochondrial pyruvate carrier (MPC) regulated by GCN4 was found to play a crucial role in GA biosynthesis under nitrogen limitation.Phospholipase D (PLD) and phosphatidic acid (PA) were also implicated in heat stress-induced GA biosynthesis.The findings highlight the complex regulatory mechanisms of GA biosynthesis in G. lucidum under environmental stress, involving multiple signaling pathways and metabolic adjustments.These insights provide a foundation for further research on fungal secondary metabolism and potential biotechnological applications.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".