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Record W4405175674 · doi:10.1016/j.jdrv.2024.12.002

Outcomes of systemic janus kinase inhibitors following dupilumab for dupilumab-associated facial and neck erythema: A systematic review

2024· review· en· W4405175674 on OpenAlexaff
Rachel S. Simpson, Siddhartha Sood, Jihad Waked, Abrahim Abduelmula, Khalad Maliyar, Muskaan Sachdeva, Asfandyar Mufti, Jensen Yeung

Bibliographic record

VenueJAAD reviews. · 2024
Typereview
Languageen
FieldMedicine
TopicAutoimmune Bullous Skin Diseases
Canadian institutionsProbity Medical ResearchHealth Sciences CentreWomen's College HospitalUniversity of TorontoSunnybrook Health Science CentreWestern University
Fundersnot available
KeywordsDupilumabJanus kinaseErythemaDermatologyMedicineJanus kinase inhibitorInternal medicineAtopic dermatitisReceptor

Abstract

fetched live from OpenAlex

Dupilumab-associated facial and/or neck erythema (DA-FNE) has been reported in up to 10% of atopic dermatitis patients in clinical practice.1,2 Studies report DA-FNE may resolve with janus kinase inhibitors (JAKi). Herein, we systematically reviewed outcomes of patients with DA-FNE who switched from dupilumab to systemic JAKi.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.010
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Meta-epidemiology (narrow), Meta-epidemiology (broad)
Consensus categoriesMeta-epidemiology (narrow)
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Systematic review · Consensus signal: Systematic review
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.235
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0030.010
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0220.007
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.036
GPT teacher head0.349
Teacher spread0.313 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; both teacher heads agree on what is shown here.

Study designSystematic review
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2024
Admission routes1
Has abstractyes

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