Segmentation of Carotid Arteries From Three-Dimensional Black-Blood Magnetic Resonance Imaging With Sparse Annotation Using a Multi-Dimensional Hybrid Model
Bibliographic record
Abstract
Quantification of carotid atherosclerosis is important in monitoring patients at risk of cardiovascular events and in evaluating therapies. High-resolution 3D carotid magnetic resonance imaging (MRI) has been developed to provide extended coverage of the carotid arteries. However, the extended coverage poses a challenge as several hundreds of 2D axial images are required to be segmented for analysis. We propose a multi-dimensional hybrid framework that requires only a sparse set of manual segmentation. Dense surrogate ground truth boundaries required to train the framework are automatically generated by propagating the sparse manual segmentation using the proposed region of interest (ROI) U-Net. Furthermore, the Point U-Net was developed to generate surrogate ground truth for carotid branches without manual segmentation. The proposed framework leverages the advantages of 3D and 2D convolution neural networks (CNNs) to segment the outer wall and lumen from 3D MRI. The 3D multiscale U-Net provides a rough outer wall segmentation, which serves as the ROI to guide outer wall and lumen segmentation by the 2D ROI U-Net. The 3D Multiscale U-Net localizes the ROI automatically, bypassing the need for manual ROI identification. The 3D Multiscale U-Net was further improved by a 3D inception module installed at the bottleneck and the novel loss functions that promote longitudinal continuity and minimize the overlap of the internal and external carotid arteries. Extensive evaluation on the publicly available Carotid Artery Vessel Wall Segmentation challenge dataset shows that our approach outperforms the top-ranked solution in the challenge and state-of-the-art segmentation methods.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.002 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".