Heterogeneous Graph Representation Learning Framework for Resting-State Functional Connectivity Analysis
Bibliographic record
Abstract
Brain functional connectivity analysis is important for understanding brain development and brain disorders. Recent studies have suggested that the variations of functional connectivity among multiple subnetworks are closely related to the development of diseases. However, the existing works failed to sufficiently capture the complex correlation patterns among the subnetworks and ignored the learning of heterogeneous structural information across the subnetworks. To address these issues, we formulate a new paradigm for constructing and analyzing high-order heterogeneous functional brain networks via meta-paths and propose a Heterogeneous Graph representation Learning framework (BrainHGL). Our framework consists of three key aspects: 1) Meta-path encoding for capturing rich heterogeneous topological information, 2) Meta-path interaction for exploiting complex association patterns among subnetworks and 3) Meta-path aggregation for better meta-path fusion. To the best of our knowledge, we are the first to formulate the heterogeneous brain networks for better exploiting the relationship between the subnetwork interactions and the mental disease We evaluate BrainHGL on the private center Nanjing Medical University dataset (center NMU) and the public Autism Brain Imaging Data Exchange (ABIDE) dataset. We demonstrate the effectiveness of the proposed model across various disease classification tasks, including major depression disorder (MDD), bipolar disorder (BD) and autism spectrum disorder (ASD) diagnoses. In addition, our model provides deeper insights into disease interpretability, including the critical brain subnetwork connectivities, brain regions and functional pathways. We also identified disease subtypes consistent with previous neuroscientific studies by our model, which benefits the disease identification performance. The code is available at https://github.com/IntelliDAL/Graph/BrainHGL.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.002 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".