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Record W4405191725 · doi:10.1002/icd.70106

Impact of Prenatal Stress on Autonomic Nervous System Functioning and Psychopathology Risk in Early Childhood: The Harvey Mom Study

2024· preprint· en· W4405191725 on OpenAlexafffund
Rebecca Lipschutz, Suzanne King, Carla Sharp, Dana DeMaster, Hanako Yoshida, David P. Laplante, David M. Olson, Johanna Bick

Bibliographic record

VenueInfant and Child Development · 2024
Typepreprint
Languageen
FieldNeuroscience
TopicAnesthesia and Neurotoxicity Research
Canadian institutionsUniversity of AlbertaJewish General HospitalMcGill UniversityDouglas College
FundersCanadian Institutes of Health Research
KeywordsPsychopathologyAutonomic nervous systemPrenatal exposurePrenatal stressPsychologyClinical psychologyDevelopmental psychologyMedicinePsychiatryInternal medicinePregnancyGestationHeart rateBlood pressure

Abstract

fetched live from OpenAlex

ABSTRACT Prior human and animal research suggests prenatal stress alters developmental systems that support stress and emotion regulation in offspring, which may underlie vulnerability to psychopathology risk. We examined prospective associations between prenatal stress from a natural disaster and infant biobehavioral outcomes across toddlerhood. Women pregnant during Hurricane Harvey in 2017 completed assessments of their objective levels of hardship and their subjective distress from the disaster. Offspring ( n = 47) completed follow‐up assessments at 24 months to collect autonomic nervous system activity (respiratory sinus arrhythmia, RSA; heart rate, HR) during a stressor task. Parents assessed their children's behavioural problems at 24 and 48 months of age. Increased objective hardship was associated with greater HR reactivity and recovery. Prenatal subjective distress was associated with increased child behaviour problems at 24 months. Higher behaviour problems at 24 months of age were also associated with HR reactivity and recovery. No significant effects with RSA reactivity or recovery were observed. Findings suggest that prenatal stress is an important predictor of offspring biobehavioral risk. Further research is needed to explore longitudinal pathways.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.037
Threshold uncertainty score0.930

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.001
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.020
GPT teacher head0.282
Teacher spread0.262 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2024
Admission routes2
Has abstractyes

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