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Record W4405285388 · doi:10.1080/17435889.2024.2439776

Nanomedicine and clinical diagnostics part I: applications in conventional imaging (MRI, X-ray/CT, and ultrasound)

2024· review· en· W4405285388 on OpenAlex
Ahmad Butt, Horacio Bach

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueNanomedicine · 2024
Typereview
Languageen
FieldEngineering
TopicNanoplatforms for cancer theranostics
Canadian institutionsUniversity of British Columbia
Fundersnot available
KeywordsMedical physicsMedical imagingNanomedicineModalitiesModality (human–computer interaction)Clinical PracticeClinical imagingMagnetic resonance imagingComputer scienceNanotechnologyMedicineArtificial intelligenceRadiologyMaterials scienceNanoparticle

Abstract

fetched live from OpenAlex

Integrating nanotechnologies in diagnostic imaging presents a promising step forward compared to traditional methods, which carry certain limitations. Conventional imaging routes, such as X-ray/computed tomography and magnetic resonance imaging, derive significant advantages from nanoparticles (NPs), which allow researchers and clinicians to overcome some of the limitations of traditional imaging agents. In this literature review, we explore recent advancements in nanomaterials being applied in conventional diagnostic imaging techniques by exploring relevant reviews and original research papers (e.g. experimental models and theoretical model studies) in the literature. Collectively, there are numerous nanomaterials currently being examined for use in conventional imaging modalities, and each imaging technique has unique NPs with properties that can be manipulated to answer an array of clinical questions specific to that imaging modality. There are still challenges to consider, including getting regulatory approval for clinical research and routine use about long-term biocompatibility, which collectively emphasize the need for continued research to facilitate the integration of nanotechnology into routine clinical practice. Most importantly, there is a continued need for strong, collaborative efforts between researchers, biomedical engineers, clinicians, and industry stakeholders, which are necessary to bridge the persistent gap between translational ideas and implementation in clinical settings.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.961
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0020.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.023
GPT teacher head0.327
Teacher spread0.304 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it