The Relief of Nociceptive Pain Induced by Panitumumab Could be Sustainable during Chemotherapy
Bibliographic record
Abstract
Anti-epidermal growth factor receptor (EGFR) antibodies and tyrosine kinase inhibitors, which are molecular-targeted drugs used in cancer treatment, are suspected to have analgesic effects on cancer-related pain. The relieving effect of EGFR inhibitors on neuropathic pain has been described to persist for approximately 20 days in patients with colorectal cancer. Since the administration of panitumumab, ananti-EGFR antibody, is repeated every 14 days, its relieving effect on cancer-related pain should be maintained until the next administration. To test this hypothesis, we investigated the chronological changes in symptoms before and two and 14 days after administration. A retrospective study using electrical patient charts demonstrated that the analgesic effects of panitumumab sustained in 8 out of ten patients with colorectal cancer (80%) until the start of next cycle of chemotherapy. The relief of nociceptive pain can be maintained in most of the patients during chemotherapy by repeated use of this agent, once pain relief has been achieved.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".