Effects of supplementation with 1,25(OH)2D3-glycoside of herbal origin in the diet of nursery piglets
Bibliographic record
Abstract
Context To provide adequate dietary vitamin D in nursery piglets, 1,25(OH)2D3-glycoside could be a potential alternative to supplements currently in use. Aims The effect of this supplement on apparent total tract nutrient digestibility, growth performance, health status, and bone traits was assessed in nursery piglets. Methods Digestibility was assessed in 30 piglets (23.8 ± 3.32 kg), and growth performance in 135 weaned piglets (8.0 ± 0.53 kg). Both trials used randomized complete block designs based on bodyweight, with five treatments: −D3: no vitamin D supplementation; +D3: 100% of the vitamin D requirement supplied as cholecalciferol; and +D3 + 0.5, 1.0, or 1.5 μg of 1,25(OH)2D3-glycoside. Key results From Day 21 to 35, piglets fed D3 + 1.0 diet showed greater average daily gain compared to −D3 or D3 + 1.5, and a greater average daily feed intake was observed in piglets fed +D3, D3 + 0.5, and D3 + 1.0 compared to −D3 or D3 + 1.5. From Day 0 to 7, diarrhoea prevalence was lower in piglets fed D3 + 1.0 compared to −D3, D3 + 0.5, and D3 + 1.5. Across the entire period, animals fed D3 + 1.0 had lower diarrhoea prevalence compared to D3 + 0.5. Serum 25(OH)D3 concentrations was lowest in −D3 piglets. Leukocyte concentrations were greater in piglets on D3 + 1.0 than with D3 + 1.5, whereas eosinophil concentrations were lowest in piglets fed D3 + 0.5. Alkaline phosphatase activity was higher in piglets on +D3 than with D3 + 0.5 or D3 + 1.5. The greatest and lowest bone Ca contents were observed in treatments D3 + 1.5 and D3 + 0.5, respectively. The bone magnesium contents was lowest in piglets fed -D3. Conclusions Adding 1,25(OH)2D3-glycoside to diets containing adequate vitamin D contents as cholecalciferol did not increase serum 25(OH)D3 concentrations, but physiological and metabolic parameters were improved and, in general, 1.0 μg of 1,25(OH)2D3-glycoside showed the best effects on performance, serum vitamin D, health status, and bone traits. Implications This research has provided new information on the effects of 1,25(OH)2D3-glycoside supplementation in diets for nursery piglets and has shown its potential use for bolstering general health.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".