A Novel Computational Model of the Zebrafish Atrial Action Potential and Intracellular Calcium Transient
Why this work is in the frame
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Bibliographic record
Abstract
The zebrafish has emerged as a valuable experimental model for studying cardiac electrophysiology and arrhythmias, yet there are no detailed computational models specific to its atrial action potential (AP) and intracellular calcium (Ca 2+ ) transient (CaT).We present a novel zebrafish-specific model, integrating experimental data from microelectrode and optical mapping recordings in the adult heart.We used a combination of experimental measurements and simulations to calibrate the model and validate it against additional experimental data.The model successfully reproduces experimentally observed atrial AP and CaT under various physiological conditions, offering a valuable tool for future work involving disease modelling, drug screening, and the investigation of cardiac arrhythmias.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it