Dyssynchrony between Endo- and Epicardial Activation in a Bilayer Model of the Left Atrium with Heterogeneous Endoepicardial Dissociation
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Endoepicardial delays in activation observed in patients with atrial fibrillation have been hypothesized to be associated with structural remodeling and layer dissociation.We aim to explore in a computer model how synchrony in endo-and epicardial activation during fibrillation is affected by local layer dissociation.A bilayer interconnected cable model of the left atrium was used to simulate atrial fibrillation on different arrhythmogenic substrates with epicardium-only diffuse fibrosis and heterogeneous endoepicardial dissociation.Activation time series were extracted in both layers to compute endoepicardial delays and a measure of synchrony based on a coincidence window.The simulations showed that reentrant activity was driven by the endocardium, thus generating an endoepicardial delay.Heterogeneous layer dissociation prolonged that delay locally.In regions with decoupled layers, the synchrony index was lower, illustrating how synchrony in activation may be related to the tissue structure.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it