Dyssynchrony between Endo- and Epicardial Activation in a Bilayer Model of the Left Atrium with Heterogeneous Endoepicardial Dissociation
Bibliographic record
Abstract
Endoepicardial delays in activation observed in patients with atrial fibrillation have been hypothesized to be associated with structural remodeling and layer dissociation.We aim to explore in a computer model how synchrony in endo-and epicardial activation during fibrillation is affected by local layer dissociation.A bilayer interconnected cable model of the left atrium was used to simulate atrial fibrillation on different arrhythmogenic substrates with epicardium-only diffuse fibrosis and heterogeneous endoepicardial dissociation.Activation time series were extracted in both layers to compute endoepicardial delays and a measure of synchrony based on a coincidence window.The simulations showed that reentrant activity was driven by the endocardium, thus generating an endoepicardial delay.Heterogeneous layer dissociation prolonged that delay locally.In regions with decoupled layers, the synchrony index was lower, illustrating how synchrony in activation may be related to the tissue structure.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".