Intermittent fasting alters tumor burden, autophagy, and metabolites in chronic lymphocytic leukemia
Bibliographic record
Abstract
ABSTRACT Emerging preclinical data suggests dietary interventions, including intermittent fasting, may play a key role in altering cancer progression. In a feasibility trial monitoring cellular, clinical, and qualitative changes, ten patients with chronic lymphocytic leukemia followed time-restricted eating for three months, and five patients for six months. Seven of fifteen participants (47%) experienced a decrease or stabilization in malignant lymphocyte counts on time-restricted eating, while malignant lymphocyte accumulation slowed in five participants (33%) or had no effect in three participants (20%). A reduction in malignant lymphocyte counts were accompanied by an unexpected decline in cellular autophagy in malignant lymphocytes. Metabolite profiling identified microbial-derived bile acid metabolites, glycoursodeoxycholic, taurochenodeoxycholic, glycolithocholic and ursodeoxycholic acid, and short-chain fatty acids, dehydrolithocholic and apocholic acid, that changed with time-restricted eating. Participant quality of life improved during time-restricted eating. These results connect time-restricted eating with shifts in autophagy, microbial-derived metabolites, tumor progression, and quality of life.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.002 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".