Successful multimodal endobronchial treatment of severe tracheobronchial amyloidosis
Bibliographic record
Abstract
A previously healthy woman in her 40s presented with a 6-month history of increasing cough and breathlessness following COVID-19 infection. She experienced vocal hoarseness and recurrent respiratory infections during this time, requiring several antibiotic courses. She was treated for gastro-oesophageal reflux and trialled on inhaled corticosteroids, without improvement. Further work up included CT scan, demonstrating tracheal thickening, endobronchial narrowing and mucosal abnormalities. Bronchoscopy with biopsies demonstrated amyloidosis. She was referred to a specialist centre with further work up including serum amyloid P component (SAP) scan, echo and bloodwork. She was diagnosed with localised tracheobronchial amyloidosis and referred to interventional respiratory for treatment. Bronchoscopy demonstrated severe narrowing in left main, left upper and lower lobes and to a lesser extent, the right main bronchus. Endobronchial treatment included diode laser therapy, electrocautery and cryorecanalisation. Significant improvement was seen on 3 months post surveillance bronchoscopy. Following this treatment, the patient experienced sustained improvement in breathlessness and cough.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".