Sprue-Like and Other Intestinal Diseases in the Common Variable Immunodeficiency (Cvid) Spectrum
Bibliographic record
Abstract
Many forms of immunodeficiency have been described. There may be about 150 different types, some with inherited or genetic causes, some with recognized specific molecular defects. Most can be classified as affecting the humoral or cellular, sometimes both, immune systems. In adults, the most common symptomatic form, albeit rare, is common variable immunodeficiency, or CVID. In recent years, it has also been suggested that rather than a single disease, CVID represents a heterogeneous group marked by panhypogammaglobulinemia and variable clinical features. In most, intestinal symptoms predominate, including, but not limited to sprue-like intestinal disease, a disorder that fails to respond to a gluten-free diet. Also, several types of colonic disease may occur similar to ulcerative colitis, Crohn’s disease and, most recently reported, collagenous colitis. Treatment of these disorders remains largely empirical and based on disease seen in the absence of CVID. Added molecular genetic studies are needed to more fully characterize the immune defects in CVID and, ultimately, to provide more evidence-based treatments.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".