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Record W4405727711 · doi:10.12691/ijcd-12-1-2

Sprue-Like Small Intestinal Diseases 2024

2024· article· en· W4405727711 on OpenAlexaff
Hugh James Freeman

Bibliographic record

VenueInternational Journal of Celiac Disease · 2024
Typearticle
Languageen
FieldMedicine
TopicGastrointestinal disorders and treatments
Canadian institutionsUniversity of British Columbia
Fundersnot available
KeywordsMedicineSprueGeneticsBiology

Abstract

fetched live from OpenAlex

Celiac disease (also termed gluten-sensitive enteropathy) is a gluten-dependent immune-mediated disorder of the small intestinal mucosa. This disease occurs in genetically-predisposed individuals and serological studies in different populations estimate that about 1% of screen-positive individuals may eventually be diagnosed with celiac disease. However, a number of other disorders, labeled sprue-like intestinal disease, may also cause the pathological appearances of celiac disease, such as mucosal injury from oats or other proteins (eg., soy), along with a wide array of infections, including protozoans, viral, bacterial and parasitic agents. Some nutrient or vitamin deficiencies including zinc, folic acid and vitamin B12 along with an array of immune deficiency syndromes may cause a sprue-like enteropathy with the histopathological features of untreated celiac disease. None of these respond to a gluten-free diet. Instead, other forms of therapy may lead to resolution. Medications including pharmacological (eg., olmesartan) and biological agents (eg., checkpoint inhibitors) may cause sprue-like small intestinal disease. Ceasing use of the medication may lead to resolution of mucosal injury

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.120
Threshold uncertainty score0.834

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.014
GPT teacher head0.293
Teacher spread0.279 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2024
Admission routes1
Has abstractyes

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