Abstracts - IANCON 2024

ID: 3: Impairment in Higher-Order Vision Predicts Cognitive Impairment and Severity in Patients with Parkinsonian Disorders Lesley Ponraj, Appaswamy Thirumal Prabhakar, Shaik Atif Iqbal ahamed Christian Medical College, Vellore, Tamil Nadu, India Background and Aim: Visual processing impairment is a phenomenon described in parkinsonian disorders (PD). Tests used in this study are dot motion test (DMT), biological motion test (BMT), and noise pareidolia test (NPT). It still remains unknown whether these tests can predict cognitive impairment and whether it will be different in various parkinson’s disease subtypes. Our aim was to see if abnormalities in the higher-order visual impairment tests predicted severity, cognitive impairment, psychosis, and subtype of parkinsonism. Methodology: This was a retrospective electronic medical record-based study done in 109 parkinsonian patients who underwent higher-order visual testing in a tertiary hospital. Results: Performance on NPT was associated with vascular PD (F = 6.128, P = 0.015). Impairment in BMT was associated with the Hoehn & Yahr (HNY) stage (F = 10.049, P = 0.002). Poor performances on DMT (F = 7.221, P = 0.008) and BMT (F = 26.541, P < 0.001) were associated with low Montreal Cognitive Assessment scores predicting cognitive impairment. However, receiver operating characteristic curves of the tests did not show any significant results to predict the subtype of PD. Conclusions: Higher-order visual testing, namely BMT and DMT, can predict the severity and cognitive impairment in patients with PD. NPT can be a tool to identify vascular contributions to PD. Abstract ID: 4: Linezolid-Induced Peripheral Neuropathy in Multidrug-Resistant Tuberculosis – A Prospective Observational Study Gaurav Chaudhary, Pawan T. Ojha, Akash Chheda, Kamlesh A. Jagiasi, Rakesh Singh, Arjun G. Shah, Anuradha P. Mahto, Aamna Maniyar, Shashank Nagendra, Billia K Appu, Karthik Gaud, Harshil Bagadia Grant Medical College and JJ Hospital, Mumbai, Maharashtra, India Background and Aim: Linezolid is used for treatment of multidrug-resistant tuberculosis (MDR TB). One of the common adverse effects associated with the treatment is peripheral neuropathy. Dose modification or interruption at the onset of peripheral neuropathy can prevent the development of irreversible deficits. We aim to study the clinical features, grade the severity of linezolid-induced peripheral neuropathy, and determine the effects of dose modification to avoid long-term deficits. Methodology: MDR TB patients on linezolid treatment who developed peripheral neuropathy were studied. National Cancer Institute Neurosensory Scale was used to grade patients into mild, moderate, and severe neuropathy. Patients with mild neuropathy were continued on linezolid 600 mg. In patients with moderate neuropathy, the dose was reduced to 300 mg, and linezolid was withdrawn for severe neuropathy patients. Follow-up was done regularly and dose modified accordingly. End result was analyzed at 18 months of tuberculosis treatment completion. Results: Eighty-four patients were included in the study. On presentation, 31 (36.9%) patients had mild neuropathy, 33 (39.28%) had moderate neuropathy, and 20 (23.8%) had severe peripheral neuropathies. Linezolid was stopped early in 41.6% patients. Improvement or stabilization of symptoms from onset was observed in 67.7% of patients in mild, 60.6% of patients in moderate, and 55% of patients in severe group. Moreover, 16.6% patients had persistent severe deficits at 18 months. Conclusions: This study highlights the importance of grading linezolid-induced peripheral neuropathy and the need to provide standard guidelines for dose modification to prevent irreversible severe deficits. Abstract ID: 5: The Utility of Clock Drawing Test and Cube Construction in Diagnosis of Early Cognitive Impairment – A Critical Analysis Sayooja Sachithanandan Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), Thiruvananthapuram, Kerala, India Background and Aim: Clock drawing test (CDT) and cube construction test (CCT) are simple-to-administer tasks which require multiple cognitive domains. This study was aimed to find out the utility of these tests in relation to global tools for screening early cognitive impairment (ECI). Methodology: All subjects meeting the inclusion and exclusion criteria were categorized into cognitively normal (CN), mild cognitive impairment (MCI), and early dementia (ED) using standard clinical criteria. The mean CDT and CCT scores as well as types of qualitative errors were compared among the three groups. Spearman’s rank correlation test was used to study the relationship of various factors with CDT and CCT, and receiver operating characteristic curve was plotted to determine the utility of these tests as a screening tool in diagnosing MCI and ED from CN. Results: A total of 228 subjects with a mean age of 69 ± 6.7 years were categorized into three groups. A cut-off score of 14 for CDT and 25 for CCT had optimal sensitivity and specificity to diagnose MCI from CN. Similar cut-off scores were obtained to diagnose ED from CN (12 for CDT and 22 for CCT). Age was negatively correlated and level of education was positively correlated to CDT and CCT score among CN subjects, but not in ECI subjects. Qualitative errors patterns of CDT were distinct among MCI and ED. Conclusions: CDT and CCT were found to be performing better in diagnosing ED from CN than MCI from CN. CDT scored better as a screening tool than CCT possibly due to better objectivity in the scoring system. Abstract ID: 6: Effect of Viewing the Event on Psychologic Outcomes in Patients with Psychogenic Nonepileptic Events (PNEE): A Randomized Controlled Trial Lakshmi Priya, Ashalatha Radhakrishnan, Ramshekhar N. Menon Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), Thiruvananthapuram, Kerala, India Background and Aim: Psychogenic nonepileptic events (PNEE) is one of the common disorders that feigns a true epilepsy or movement disorder, yet there are no current treatment guidelines to manage it even after setting up the diagnosis. This study aimed to determine the effect of viewing one’s own event as a novel treatment strategy in PNEE. Methodology: This was a single-center, double-blinded, randomized controlled trial, where patients with at least one habitual psychogenic event recorded in the epilepsy monitoring unit were recruited. The participants were randomized (1:1) into two arms and all were given standard psychotherapy, while the intervention arm patients were shown their own recorded event in addition. The psychologic status (primary outcome), measured using standard questionnaires Hospital Anxiety and Depression Scale (HADS) and Quality of Life In Epilepsy-31 (QoLIE- 31) and event frequency (secondary outcome), was compared between baseline and follow-up at 3 months. Wilcoxon singed-rank test and Chi-square test were used to compare both the arms. Trial Registration information: CTRI/2021/04/033220 Results: Sixty-five participants (31 in the intervention /34 in the with a mean age of years in the intervention arm and years in the arm were recruited. scores in the intervention significant in to P = of to P = and to P = compared to the scores in the group. and event frequency in both the arms. Conclusions: Event viewing psychologic status in and adverse Abstract ID: Utility of in Prospective and in A Prabhakar, Christian Medical College, Vellore, Tamil Nadu, India Background and Aim: with severe the need for as for Our study aimed to determine the of with features, and visual impairment and to predict in disease Methodology: Our study was a retrospective study of patients with between and Visual included visual and Patients were on the of impairment as mild, and was using for the Sciences were significant at Results: In were the age of patients was 31 The follow-up was months. included with normal with mild impairment and with severe impairment Patients with severe impairment had compared to patients with normal and patients with mild impairment = significant correlation with of and of impairment in the in all with early in the and in the = in and baseline correlated with had a correlation with P = P = Conclusions: The with and in better of disease status and as a for Abstract ID: in of and in Patients with All India Institute of Medical India Background and Aim: due to is the severe of early and monitoring of The and of the study were to in patients using with study of the disease monitoring Scale with and with Methodology: patients in the of were was two and at and follow-up after were and correlated with various and using for the Sciences Results: of 33 patients who underwent patients at out of patients of stage 3 and out of patients of stage had was significant correlation between and with patients with treatment after On with found there was correlation at different at and at 3 Conclusions: can be used as a for early of in patients. Abstract ID: the in Patients with Ramshekhar Ashalatha Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), Thiruvananthapuram, Kerala, India Background and Aim: epilepsy for of for epilepsy The is to find whether the in a in predicting the in patients with Methodology: We included patients who underwent a clinical and a standard from to were up at 3 and with The was into if did not or of the and even if a Results: the had had had for the had and had All the were in of the In of the study had the The mean follow-up was months with a follow-up of 14 with had of at the follow-up = as a were found = and was a = was associated with = significant with was found for the of or Conclusions: and had a and The of different had no correlation with Abstract ID: with A of Background and Aim: as global in is for these and However, optimal This study a intervention to epilepsy and Methodology: in a of the study epilepsy education in and A a intervention baseline epilepsy a intervention on the and This in the and It included and on epilepsy and The study to identify to and for epilepsy and after the Qualitative used to Results: This intervention and a of screening and in 3: and epilepsy and the as and in epilepsy Conclusions: This intervention epilepsy screening and in and and in on and this a to the of with epilepsy Abstract ID: and of in Patients Shah, Hospital and Maharashtra, India Background and Aim: is a in of and of patients from epilepsy We aimed to determine the factors in of patients. Methodology: This retrospective study included patients of to the between and clinical and status were Results: age at presentation, onset and epilepsy at were and onset years of age predicted on out of patients had had had and had of had in the of in to 14 had and had patients underwent of 20 had and three had was in of patients. All the patients with had on was in of patients patients had and of these had and patients had On three patients had and had while patients had Conclusions: of and and was associated with a Abstract ID: in with – A Study G. National Institute of and India Background and Aim: in with epilepsy the of but remains This the factors to and in to Methodology: A study was with from a in India between and The included on and on criteria were years with epilepsy and on treatment for at least a were in the age included and and clinical were was using the Scale and the symptoms were using the Anxiety and Scale was Results: were groups. The had a age of epilepsy epilepsy treatment and was found in of with was the common had the with treatment and symptoms were in the group. predicted = Conclusions: This study in India into the between and in Abstract ID: The and of in of a Medical Background and Aim: in can be of which not any clinical monitoring The of this study was to diagnose the frequency of and in a The was to the in of the of Methodology: A of in patients between the of and of was at a in The patients were into A patients with and as patients with of but no and a of patients with clinical of Results: was in patients of A and patients of The monitoring was 18 A total of were of which had clinical the patients with were to be in the medical of of In the = were recorded in of patients. of these patients were found to be in status The of from to = and from to < 0.001) in A and compared to the group. Conclusions: The study highlights in and while a Abstract ID: A Study of the in National Institute of and India Background and Aim: and in the of The of the which as and is the of not in This study aimed to study the of the in and with the clinical and Methodology: patients with and were from a unit after from to of the and were using the The the study. Results: The of and were in compared to = and P = were between the and the clinical severity or subtypes. Conclusions: a to the of and with and of these provide better into their and their in the of these and peripheral Abstract ID: A for with A Randomized Controlled Trial for Maharashtra, India Background and Aim: Cognitive impairment and dementia significant for as the a for the of with mild cognitive impairment or dementia and their in Methodology: This randomized controlled to as a intervention for and with the study will participants from and to the intervention or Results: The will that the intervention cognitive and in compared to in the intervention will show and to with observed Conclusions: This to provide on the of in the of with the development of a for this Abstract ID: of in with National Institute of and India Background and Aim: are in with a of compared to and are and a in Our aim was to the of in and on in and Methodology: A study was in of and and at National Institute of and between and after were using from and years were with of and and was using and was the Results: This study found in of and of < between and = with positively with = and = correlated with = and < significant were found for and in no between and were found in group. a significant in correlation with the for in Abstract ID: of to Outcomes in of Medical College, Maharashtra, India Background and Aim: is a of and in the but are not used in clinical This study to the of in of at 3 months using and clinical Methodology: A study from a medical in India was from to of patients with were and at 3 months modified Scale into and was using on was used for Results: A total of patients were of were their mean age was ± was ± the had at 3 months with and had as the with sensitivity and a receiver operating characteristic the curve of Conclusions: We developed which can predict of at 3 months with of can in patients and the and after Abstract ID: of and for in A of All India Institute of Medical India Background and Aim: is a of and and are to yet their remains This study to compare these a Methodology: We a of a of standard treatment and with was to the of treatment in in or in Results: A total of randomized controlled and were included in between and a associated with = a with In was found to a compared to a with and no significant The that and as Conclusions: on these to treatment and in Abstract ID: Effect of on in Patients with – A Study and Hospital, India Background and Aim: on as and current shown results in patients after a However, their effects on patients with not well studied. Methodology: This was a double-blinded, randomized inclusion and exclusion patients were and randomized into two groups. One of to the the The were a in the and test scores on the of Medical at after the of Results: had baseline results at after compared to baseline were significant in the P = 0.002). results at after compared to baseline were significant in the P = score results at after compared to baseline were significant in the P = 0.002). results were obtained in the = A of the and a significant effect of both and on both as a (F = P = for = P = for and = P = for Conclusions: is in patients with after but are to these Abstract ID: of in Patients with at 3 of the Event – A Prospective Study Singh, All India Institute of Medical India Background and Aim: is the of and of in Our aim was to of Scale at 3 months and early National of Scale or of at in patients. Methodology: A study patients with of the inclusion and exclusion criteria was from Results: the were a mean age of years were were had and that and had disease of and of Scale at presentation, Early to to and to were 3 and In had and On age of at and at presentation, of Trial of in of of on of of who did not from to and reduced of all were factors for at 3 months. On performing at presentation, of and of were significant of at 3 months after for the in age and at of with of P = and P = of and of had of with of and On performing of of and were of the in at of with of P < of of and of with of and Conclusions: factors in patients. Abstract ID: and of – A Study of from a of Kerala, India Background and Aim: from to in and from to in Our aim was to the clinical and of after in a study of from a We to the and of after Methodology: We a retrospective of patients who underwent with at Hospital from to Patients with were National of modified of or of and treatment were were from electronic medical Results: of a were and 18 were these had had and two had The was in patients and in patients of the patients to their with the common of of their Conclusions: Our study the need for monitoring and of factors in a months of for and for Abstract ID: of Disorders in A Prospective Study in a Hospital Medical College and Hospital India Background and Aim: disorders are the of or as and than their is for treatment and This study aimed to find out the clinical of various in and to their and Methodology: A study was from to in a tertiary in from months to years of age with to the and of and were and clinical were out with a A was and results were analyzed to find the of and their Patients were up a of 3 months for the Results: of were in and in = = and = were among were = Conclusions: of to this of India are and A significant of had than one of Early and are for better Abstract ID: and of and in – from a K Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), Thiruvananthapuram, Kerala, India Background and Aim: We aimed to the clinical and of patients with and for treatment in and the to 20 Methodology: We the electronic medical of patients with and who had at least two to We analyzed the clinical at and the for of the with and adverse Results: We had patients with who were and had at least one and of had and were was the common to was in patients. with as the to the of to The mean to was The of and of were found to be of with Conclusions: Our study for the to in a of a clinical The study observed that the of onset in is associated with the of to Abstract ID: and in A Prospective Study and India Background and Aim: disease to patients who disease in and This study to the of symptoms and in Methodology: This the included patients with disease the for with age at onset between and Patients underwent Hoehn and Yahr & and using Scale and Quality after their was on patients after on with patients and was the Results: A total of patients were in the of 20 and age of onset was years with the of modified & stage is was in of the where patients had of the the was for symptoms 20 in 20 and symptoms in 14 and disorders were with and in patients were and patients their as Conclusions: patients significant symptoms and with a and are to these Abstract ID: and of in a Hospital in a Medical Hospital in A Study Hospital, Medical College India Background and Aim: are a of with the common The a for these This study aimed to the clinical and severity of NPT in a tertiary in India using the Methodology: This study patients than or to 18 years with NPT the movement at a tertiary in 14 months. Patients underwent a clinical the for and the Scale for severity Results: The of NPT was in the and in the movement was the subtype disorders and and had of the study were observed in age of and severity among subtypes. Conclusions: This study a of NPT clinical and severity in a using the The the of NPT the of the and the importance of and is to and in the Abstract ID: of in Ashalatha Radhakrishnan, Ramshekhar N. Menon Thiruvananthapuram, Kerala, India Background and Aim: of all and are as disorders with to the on the of testing in We aimed to study the of and their on the of and Methodology: We a retrospective study of with of all between and The the criteria for epilepsy with were and the was was as College of Medical and The were on into and and the and were compared between of were Results: the who underwent testing between and patients were and multiple were between and = = = = and = in the The factors associated with the of were the of in to global = = of = = of = and = Conclusions: of epilepsy significant in predicting and Abstract ID: Analysis of a of in a Hospital Shaik Medical College, Background and Aim: is a in the The clinical are and We aimed to study the of and to the common in and of the Methodology: This is study 14 the and of a a of was in 14 clinical and Results: tests different in patients and one novel Conclusions: This is a of in and one novel was It was found that patients with the can with clinical and Patients can be as testing and Abstract ID: of in Patients to a Medical College and Hospital, Mumbai, Maharashtra, India Background and Aim: with are and are these tests and in be with their and We a study the of in Methodology: We included patients of and the of a tertiary between and for this study. was in these patients due to of as the clinical guidelines after a Patients with of unknown were testing to the Results: patients a of patients and patients did not show any to 55% after testing in the group. was for the and was in in movement disorders was epilepsy at which is than in Moreover, of patients significant in treatment after Conclusions: This study clinical it to and treatment of patients in clinical Abstract ID: of and Outcomes Karthik National Institute of and India Background and Aim: the of in and at that predict treatment Methodology: = patients with a clinical and of to the College of and between and were included in this retrospective study after from the was done as and using Results: The patients had a mean follow-up of ± months. The mean age of onset was ± The clinical = = = and = On = and = were and both and & follow-up the treatment = = = and = of disease was as = = = = and = = that a score of Test at baseline < and a of < were of predict with a sensitivity of and specificity of with the curve operating Conclusions: This study the for in which can in early and who from early with A was which with in tertiary Abstract ID: A Study of and of or – A Observational Study Anuradha Mahto, Kamlesh Jagiasi, Pawan Ojha, Gaurav Chaudhary, Rakesh Singh, Akash Chheda, Arjun Shah, Karthik Harshil Shashank Grant Medical College & JJ Hospital, Mumbai, Maharashtra, India Background and Aim: is associated with disorders or We aimed to study the in the clinical and features, treatment and of compared to patients. Methodology: A retrospective study was in the of in a tertiary from to was from and from the was Results: patients who with 14 and were A and with was in and In of had normal On both the a significant in the modified Scale patients at least one and Conclusions: Patients with had clinical and compared to with However, the to early is and and Abstract ID: and – A of and Prabhakar, Hospital Background and Aim: is with of to and found a relationship between and that both can be to be is a of the it to However, the of the relationship remains This study aimed to the correlation of and in the severity of of and to the of Methodology: This study patients who at from to and Test were and results were in Results: were with a mean of of disease was and were associated with psychologic and with a of patients had in the 3 out of patients were with with a found in 69 patients < was as as the baseline level in patients of = It was found that these were associated with a severe on Conclusions: and are to be used as a for Abstract ID: of Hospital and Maharashtra, India Background and Aim: study the clinical of with to treatment as well as the clinical Methodology: patients between and were included in the study. Results: of patients had that had and of patients had In had had patients had and had had had had had and had had 55% had and had patients had reduced was in of patients. was in of patients. Conclusions: of patients can and than and is common than is the common and can be in and in of patients. can be in and can be in patients show with Abstract ID: The Study – of Disorders and

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