A Study on the Bi-directional Relationship Between Sleep Disturbance and Alzheimer’s Disease
Bibliographic record
Abstract
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by gradual memory loss and cognitive decline. This multifactorial condition is influenced by aging, genetic predispositions, and various lifestyle factors. Among these, sleep has emerged as a critical component of overall health, with recent research highlighting a bi-directional relationship between sleep disturbances and AD. On one hand, poor sleep may contribute to the onset and progression of AD by exacerbating pathological processes; on the other hand, the accumulation of AD-related pathologies can further disrupt sleep. Notably, slow-wave sleep (SWS) has emerged as a key overlapping factor in this relationship. By examining the interplay between sleep disorders—such as insomnia, obstructive sleep apnea (OSA), and narcolepsy—and AD, this article seeks to deepen the understanding of their shared mechanisms. Ultimately, unraveling this complex relationship may provide new insights into the etiology of AD and pave the way for innovative treatment strategies aimed at mitigating the impact of sleep disturbances on disease progression.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.001 | 0.004 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".