Avances y desafíos en el tratamiento de la insuficiencia hepática aguda
Bibliographic record
Abstract
La Insuficiencia Hepática Aguda (IHA) es un síndrome caracterizado por un deterioro grave de la función hepática en pacientes sin antecedentes de enfermedad hepática crónica (Kwong et al., 2019; Maiwall et al., 2024). En la mayoría de los casos, se produce una necrosis masiva de hepatocitos, aunque en patologías como el hígado graso agudo del embarazo, se pueden identificar otros hallazgos específicos como esteatosis microvesicular difusa con disfunción mitocondrial severa. Aunque la IHA es una entidad poco frequente en la población general, es una patología de gran importancia dada su elevada mortalidad, siendo el manejo de soporte en las unidades de paciente crítico y el trasplante hepático sus principales estrategias terapéuticas (Kwong et al., 2019).
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.005 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".