Metachronous Breast and Lung Cancers in a Middle-Aged Woman with Peutz-Jeghers Syndrome
Bibliographic record
Abstract
We report the case of a middle-aged woman with Peutz-Jeghers syndrome who developed metachronous breast and lung cancers, because lung cancer is infrequently associated with PJS, especially for women with this disorder. At the age of 12 years, the patient was diagnosed with Peutz-Jeghers syndrome owing to the presence of multiple hamartomatous polyps in the gastrointestinal tract and mucocutaneous melanin pigmentation. She developed breast cancer and underwent curative mastectomy and postoperative adjuvant chemotherapy at 48 years of age. Five years later, computed tomography showed multiple lung nodules. The pathological diagnosis of the lung lesion was a mucinous adenocarcinoma, which differed from that of the resected breast cancer. She then received cisplatin/ pemetrexed therapy combined with pembrolizumab for non-small cell lung cancer, which reduced the size of the lung tumors. However, the disease eventually progressed, and she underwent a gene panel test because of the refractoriness to pharmacotherapy, which demonstrated a germline STK11 pathogenic variant.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".