S1PR Modulators in the Management of Ulcerative Colitis: Considerations for Practice
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Sphingosine-1-phosphate receptor (S1PR) modulators are novel oral small-molecule therapies that offer a unique profile compared to other advanced therapies in the treatment of ulcerative colitis (UC), including oral administration, linear pharmacokinetic profiles, reduced immunogenicity, and lower costs associated with manufacturing. The activation of S1P G-protein coupled receptors plays an inflammatory role in UC by promoting lymphocyte egress from lymphoid organs into circulation and colonic mucosa. S1PR modulators lead to internalization and degradation of these receptors, thereby reducing inflammation. Ozanimod was the first S1PR modulator approved for treating moderately-to-severely active UC and is also approved for multiple sclerosis. More recently, a second agent, etrasimod, was approved for UC. Etrasimod acts on different S1PR subtypes to avoid off target vascular and cardiac effects, has no up-titration regimen during initiation, a shorter half-life and less propensity for drug interactions. This review summarizes clinical trial and real-world data and provides guidance on the clinical uses of S1PR modulators.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it