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Record W4406141918 · doi:10.1371/journal.pgph.0003097

Repeatability of RRate measurements in children during triage in two Ugandan hospitals

2025· article· en· W4406141918 on OpenAlexafffund
Ahmad Asdo, Alishah Mawji, Isaac Omara, Ivan Aine Aye Ishebukara, Clare Komugisha, Stefanie K. Novakowski, Yashodani Pillay, Matthew O. Wiens, Samuel Akech, Florence Oyella, Abner Tagoola, Niranjan Kissoon, J. Mark Ansermino, Dustin Dunsmuir

Bibliographic record

VenuePLOS Global Public Health · 2025
Typearticle
Languageen
FieldMedicine
TopicPneumonia and Respiratory Infections
Canadian institutionsB.C. Women's Hospital & Health CentreUniversity of British Columbia
FundersBiotalent CanadaGrand Challenges CanadaWellcome Trust
KeywordsRepeatabilityIntraclass correlationMedicineRespiratory ratePneumoniaTriageAge groupsRespiratory systemPediatricsInternal medicineEmergency medicineStatisticsHeart rateDemographyMathematicsBlood pressure

Abstract

fetched live from OpenAlex

Pneumonia is the leading cause of death in children globally. In low- and middle-income countries (LMICs) pneumonia diagnosis relies on accurate assessment of respiratory rate, which can be unreliable when completed by nurses with less-advanced training. To inform more accurate measurements, we investigate the repeatability of the RRate app used by nurses in Ugandan district hospitals. This secondary analysis included 3,679 children aged 0-5 years. The dataset had two sequential measurements of respiratory rate collected by 14 nurses using the RRate app. We measured agreement between respiratory rate observations while indicating observations' clustering around WHO fast-breathing thresholds. WHO thresholds are 60 breaths per minute (bpm) for under two months (Age-1), 50 bpm for two to 12 months (Age-2), and 40 bpm for 12.1 to 60 months (Age-3). We assessed the repeatability of the paired measurements per user through the Intraclass Correlation Coefficient (ICC) and calculated an overall ICC value. The respiratory rate measurement took less than 15 seconds for 7,277 (98.9%) of the measurements. Despite respiratory rates clustering around WHO thresholds, breathing classification based on the thresholds (Fast vs normal) was altered between sequential measurements in only 12.6% of children. The mean (SD) respiratory rate by age group was 60 (13.1) bpm for Age-1, 49 (11.9) bpm for Age-2, and 38 (10.1) for Age-3, and the bias (Limits of Agreements) were 0.3 (-10.8-11.3) bpm, 0.4 (-8.5-9.3) bpm, and 0.1 (-6.8, 7.0) bpm for Age-1, Age-2, and Age-3 respectively. The repeatability of the paired respiratory rate measurements was high, with an ICC ≥ 90% for 12 of 14 users and an overall ICC value (95% CI) of 0.95 (0.94-0.95). The RRate measurements were efficient and repeatable. The simplicity, repeatability, and efficiency support its usage in LMICs healthcare facilities, and endorses a more widespread clinical adoption.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.013
Threshold uncertainty score0.486

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.046
GPT teacher head0.365
Teacher spread0.318 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations3
Published2025
Admission routes2
Has abstractyes

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