← Back to cohort
Sepsis subtypes and differential treatment response to vitamin C: biological sub-study of the LOVIT trial
Jennifer Rynne, Mia Mosavie, Marie-Hélène Masse, Julie Ménard, Marie‐Claude Battista, David M. Maslove, Lorenzo Del Sorbo, Charles St-Arnaud, Frédérick D’Aragon, Alison Fox‐Robichaud, Emmanuel Charbonney, Neill K. J. Adhikari, François Lamontagne, Manu Shankar‐Hari, Michaël Chassé, Pierre Aslanian, Sylvain Bélisle, Jean‐François Cailhier, François Martin Carrier, André Denault, Martin Girard, Jean‐Gilles Guimond, Antoine Halwagi, Paul L. Hebert, Christophe Kolan, Caroline Ouellet, Nicholas Robillard, Fatna Benettaib, Dounia Boumahni, Martine Lebrasseur, Maya Salamé, M Cantin, Patrick Archambault, Christine Drouin, Estel Duquet-Deblois, Monia Noël-Hunter, Jean-Nicolas Dubé, Marie-Josée Bériault, Marco Chacon, David Claveau, Jean-François Naud, Danielle Tapss, Guylaine Toupin, Han Ting Wang, Marc Brosseau, Brian Laufer, François Marquis, Francis Toupin, Danaë Tassy, Vincent Cheung, Sam-Ang Toun, Dominique Bérard, Brian Grondin-Beaudoin, Marc-André Leclair, Olivier Lesur, Michaël Mayette, Yannick Poulin, Hector Quiroz Martinez, Élaine Carbonneau, Julie Bélisle, Marie-Pier Bouchard, Line Côté, M. Ladouceur, Joannie Marchand, Alexandra Naisby, Louise Robert-Petit, Marie-Ève Thibault, Martin Albert, Françis Bernard, Alexandros Cavayas, Karim Serri, David M. Williamson, Virginie Williams, Julia Palacios, François Lauzier, Charles Francoeur, Guillaume Leblanc, Maude St‐Onge, Alexis F. Turgeon, David Bellemare, Marie-Claude Boulanger, Eve Cloutier, Gabrielle Guilbault, Frédérique Thibeault, Emilie P. Belley‐Côté, Maureen O. Meade, Richard Whitlock, Lori Hand, Leah Hayward, Courtney Mullen, Nevena Savija, François Lellouche, Mathieu Simon, Ying Tung Sia, Patricia Lizotte, Bram Rochwerg, Tina Millen, J Gordon Boyd, John Drover, John Muscedere, Stephanie Sibley, Tracy Boyd, Miranda Hunt, Tina Mele, Tracey Bentall, Chadia ElKhatib, Jason Shahin, Kosar Khwaja, Josie Campisi, Norine Alam, Raham Rahgoshai, Sangeeta Mehta, Michael E. Detsky, Sumesh Shah, Sonny Kohli, Fulan Cui, Vikas Khera, David McConachie, Sachdeep Rehsia, D. Bharti, Adic Pérez, Demetrios J. Kutsogiannis, Raiyan Chowdhury, Jon Davidow, Curtis Johnston, Michael Kim, Kimberley Macala, Sam Marcushamer, D. Markland, Doug Matheson, Arabesque Parker, Damian Paton-Gay, Tayne Hewer, Patrica Thompson, Waleed Alhazzani, Erick Duan, Tania Ligori, Mark Soth, France Clarke, Mary Copland, Karlo Matic, Andre Amaral, B. H. Cuthbertson, Dominique Piquette, Damon C. Scales, Bourke W. Tillmann, Hannah Wunsch, Nicole Marinoff, Maneesha Kamra, Navjot Kaur, D. Murali, Thivya Sabananthan, Thuva Sugumaran, Andrew Seely, Shane English, Hilary Meggison, Sherissa Microys, Scott J. Millington, Aimee Sarti, Jessica Haines, Sydney Miezitis, Rebecca Porteous, Irene Watpool, Eddy Fan, John Granton, Hesham Abdelhady, Tina Romagnuolo, Oleksa Rewa, Sean M. Bagshaw, Michael L. Meier, Wendy Sligl, Nadia Baig, Gordon Wood, Daniel Ovakim, F. C. Auld, Gayle Carney, Deborah Parfett, Rémi Leblanc, Maryse Williston, Jackie Caissie Collette, Mélissa Daigle, Bernise Gaudet, Karine Morin, Lola Ouellette-Bernier, M. Villettaz Robichaud, Joanne Rockburn, Armand Mekontso Dessap, Romain Arrestier, François Bagate, Inès Bendib, Brice Benelli, Astrid Bertier, Pedro Cavaleiro, Nicolas de Prost, Ségolène Gendreau, Otto Hartman, Anne-Fleur Haudebourg, Julien Lopinto, Paul Masi, Gaël Michaud, Keyvan Razazi, Samuel Tuffet, Aline da Silva Alves, Luiza Nait Chabane, Fariza Ouali, R. Ouedraogo, Djillali Annane, Lilia Abdeladim, Rania Bounab, Nicholas Heming, Virginie Maxime, Pierre Moine, Isabelle Bossard, Ségolène Jourdier, Siline Mahiou, Hayette Tessa, Shay McGuinness, Jonathan Ball, Immanuel Hennessy, Maurice Hogan, Magdalena Butler, Keri-Anne Cowdrey, Eileen Gilder, Rachael Parke, Samantha Ryan, Melissa Woollett, Andrew Poll, Kerry A Benson-Cooper, Jonathan Chen, Kirk Freeman, David Harley, Dave Harvey, Craig Hourigan, Stephen Lo, Colin McArthur, Stuart J. Miller, Chris Pointer, R. A. Smith, Laura Tincknell, Rachael McConnochie, Catherine Simmonds, Geoffrey M. Shaw, Toby Betteridge, Brandon Burke, David Closey, Rosalind Crombie, Neil Davidson, Louise M. Henderson, Seton Henderson, Louise Hitchings, David Knight, Christine Quigley, Jay Ritzema Carter, Jessica Roberts, Katherine Townend, Tara Doyle, Jan Mehrtens, Stacey Morgan, Anna Morris, Kymbalee Van Der Heyden, Paweł Twardowski, Martin Dvořáček, Markus Renner, David Silverman, Myles Smith, Hansjörg Albert Waibel, Stefan Wiebe, Mark Woolley, Dawn France, Ulrike Buehner, Erin Williams, Troy Browne, Owen Callender, Sheila Farrell, Vicky Higson, David Jackson, Owen Keet, Jennifer Goodson, Robert Martynoga, Kelly Byrne, Amelia Butler, Kara Trask, Gay Mans, Jonathan Termaat, Paul J. Young, Colin Barnes, Ben Barry, Kim Grayson, James Moore, Alex Psirides, Shawn Sturland, Kate Tietjens, Bob Ure, Laurence Walker, Jason Wright, April Aguilar-Dano, Kirsha Delaney, Cassie Lawrence, Mildred Lesona, Alexandra Millington, Leanlove Navarra, Shaanti Olatunji, Raulle Sol Cruz, Rhoze Sol Cruz, Chelsea Young, Andrew G. Day, Deborah J Cook, Gordon Guyatt, Sheila Sprague, Dian Cohen, Daren K. Heyland, Ruxandra Pinto, Salmaan Kanji, Bharath Kumar Tirupakuzhi Vijayaraghavan, Yaseen M. Arabi
Bibliographic record
VenueIntensive Care Medicine · 2025
Typearticle
Languageen
FieldNursing
TopicVitamin C and Antioxidants Research
Canadian institutionsInstitute for Work & HealthHealth Sciences CentreCentre Hospitalier de l’Université de MontréalKingston Health Sciences CentreMcMaster UniversityUniversité de SherbrookeQueen's UniversityUniversity of TorontoToronto General HospitalSunnybrook Health Science CentreCentre Hospitalier Universitaire de Sherbrooke
FundersLotte and John Hecht Memorial Foundation
KeywordsMedicineSepsisInternal medicineConfidence intervalOdds ratioSeptic shockPlaceboVitamin D and neurologyRandomized controlled trialVitaminPathology
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.004
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.493
Threshold uncertainty score0.472
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.004 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.037
GPT teacher head0.353
Teacher spread0.316 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations14
Published2025
Admission routes2
Has abstractno