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Record W4406170333 · doi:10.1038/s41598-024-83867-6

Task relevant autoencoding enhances machine learning for human neuroscience

2025· article· en· W4406170333 on OpenAlexafffund
Seyedmehdi Orouji, Vincent Taschereau‐Dumouchel, Aurelio Cortese, Brian Odegaard, Cody A. Cushing, Mouslim Cherkaoui, Mitsuo Kawato, Hakwan Lau, Megan A. K. Peters

Bibliographic record

VenueScientific Reports · 2025
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicCell Image Analysis Techniques
Canadian institutionsUniversité de MontréalInstitut Universitaire en Santé Mentale de Québec
FundersExploratory Research for Advanced TechnologyFonds de Recherche du Québec - Santé
KeywordsTask (project management)Computer scienceNeuroscienceArtificial intelligenceData scienceCognitive sciencePsychology

Abstract

fetched live from OpenAlex

In human neuroscience, machine learning can help reveal lower-dimensional neural representations relevant to subjects' behavior. However, state-of-the-art models typically require large datasets to train, and so are prone to overfitting on human neuroimaging data that often possess few samples but many input dimensions. Here, we capitalized on the fact that the features we seek in human neuroscience are precisely those relevant to subjects' behavior rather than noise or other irrelevant factors. We thus developed a Task-Relevant Autoencoder via Classifier Enhancement (TRACE) designed to identify behaviorally-relevant target neural patterns. We benchmarked TRACE against a standard autoencoder and other models for two severely truncated machine learning datasets (to match the data typically available in functional magnetic resonance imaging [fMRI] data for an individual subject), then evaluated all models on fMRI data from 59 subjects who observed animals and objects. TRACE outperformed alternative models nearly unilaterally, showing up to 12% increased classification accuracy and up to 56% improvement in discovering "cleaner", task-relevant representations. These results showcase TRACE's potential for a wide variety of data related to human behavior.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.004
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: none
GenreCandidate signal: Methods · Consensus signal: Methods
Teacher disagreement score0.001
Threshold uncertainty score0.008

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.004
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0010.001
Open science0.0000.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.010
GPT teacher head0.297
Teacher spread0.288 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designSimulation or modeling
Domainnot available
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes2
Has abstractyes

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