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Record W4406171516 · doi:10.1016/j.neuron.2024.12.008

Toward a functional future for the cognitive neuroscience of human aging

2025· review· en· W4406171516 on OpenAlexafffund
Zoya Mooraj, Alireza Salami, Karen L. Campbell, Martin J. Dahl, Julian Q. Kosciessa, Matthew R. Nassar, Markus Werkle‐Bergner, Fergus I. M. Craik, Ulman Lindenberger, Ulrich Mayr, M. Natasha Rajah, Naftali Raz, Lars Nyberg, Douglas D. Garrett

Bibliographic record

VenueNeuron · 2025
Typereview
Languageen
FieldMedicine
TopicDementia and Cognitive Impairment Research
Canadian institutionsMcGill UniversityBaycrest HospitalBrock University
FundersCanadian Institutes of Health ResearchMax-Planck-Institut für BildungsforschungCanada Research ChairsUniversity College LondonNational Institute on AgingInternational Max Planck Research School for Advanced Methods in Process and Systems EngineeringInternational Max Planck Research School for Environmental, Cellular and Molecular MicrobiologyDeutsche ForschungsgemeinschaftBrightFocus Foundation
KeywordsNeuroscienceCognitive neurosciencePsychologyCognitionCognitive scienceCognitive agingFunctional neuroimagingDevelopmental cognitive neuroscienceFunctional connectivityCognitive psychology

Abstract

fetched live from OpenAlex

The cognitive neuroscience of human aging seeks to identify neural mechanisms behind the commonalities and individual differences in age-related behavioral changes. This goal has been pursued predominantly through structural or "task-free" resting-state functional neuroimaging. The former has elucidated the material foundations of behavioral decline, and the latter has provided key insight into how functional brain networks change with age. Crucially, however, neither is able to capture brain activity representing specific cognitive processes as they occur. In contrast, task-based functional imaging allows a direct probe into how aging affects real-time brain-behavior associations in any cognitive domain, from perception to higher-order cognition. Here, we outline why task-based functional neuroimaging must move center stage to better understand the neural bases of cognitive aging. In turn, we sketch a multi-modal, behavior-first research framework that is built upon cognitive experimentation and emphasizes the importance of theory and longitudinal design.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.006
Threshold uncertainty score0.018

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0030.003
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0030.002
Science and technology studies0.0010.003
Scholarly communication0.0030.007
Open science0.0010.002
Research integrity0.0030.006
Insufficient payload (model declined to judge)0.0060.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.119
GPT teacher head0.426
Teacher spread0.308 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations28
Published2025
Admission routes2
Has abstractyes

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