Adipose Micrograft and Its Derived Mesenchymal Stem Cells with Their Exosomes in a Hyaluronic Acid Scaffold in Infiltrative Therapy in La Peyronie's Disease or Induratio Penis Plastica: A Pilot Study and Cases Report
Bibliographic record
Abstract
The aim of this clinical study was to demonstrate that through a micrograft of viable adipose tissue of cells and its exosomes microfiltered at 35 microns to exclude fibrous shoots and cell debris in a suspension of hyaluronic acid were able to improve symptoms and clinical manifestations of Peyronye's curvature disease or IPP Induratio Penis Plastica with a beneficial effect also in plaques . Background and Objectives: Events leading to Induratio Penis Plastica (PPI) or Peyronie's disease may be discovered in an abnormal healing response within the tunica albuginea. From an anatomopathological point of view, Peyronie's disease derives from an excessive production of extracellular matrix deposited by fibroblasts with the formation of fibrotic tissue that leads to a retractile cicatricial outcome. The clinical course is characterized by an acute phase and a subsequent chronic phase with stabilization of symptoms. Events leading to Induratio Penis Plastica (PPI) or Peyronie's disease may be discovered in an abnormal healing response within the tunica albuginea. Materials and Methods: This study involved 12 patients with a history of symptoms characterized by curvature of the penis and painful erections were analyzed and subjected to this pilot study to verify the improvement of the anatomical area through a suspension containing 1.5 mL of viable micrografts from adipose tissue of cells and its exosomes in a 1.5 mL of hyaluronic acid evaluated by using a modified Vancouver scale. Results: The Modified Vancouver scales showed that with this technique it was possible to obtain excellent results both when the suspension was injected into plaques of Peyronie’s disease when it was injected with the unique pomphs technique, with the intent to revitalize the tissue through progenitors with adult stemness markers. Conclusions: The combination of microfragmented and microfiltered adipose tissue of cells and its exosomes at 35 microns in a scaffold of hyaluronic acid is safe new method to treat Peyronye’s disease or IPP Induratio Penis Plastica.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".