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Insights of SEDRIC, the Surveillance and Epidemiology of Drug-Resistant Infections Consortium

2025· preprint· en· W4406324848 on OpenAlexaff
Nicholas Feasey, Raheelah Ahmad, Elizabeth A. Ashley, Rifat Atun, Kate S. Baker, Francesca Chiari, H. Rogier van Doorn, Alison Holmes, Timothy Jinks, Andrew Jermy, Jyoti Joshi, Souha S. Kanj, Matt King, Direk Limmathurotsakul, Janet Midega, Mirfin Mpundu, Jamie G Nunn, Iruka N. Okeke, S. W. J. Reid, Dawn Sievert, Paul Turner, Kāmini Walia, Sharon J. Peacock

Bibliographic record

VenueWellcome Open Research · 2025
Typepreprint
Languageen
FieldImmunology and Microbiology
TopicAntibiotic Use and Resistance
Canadian institutionsStantec (Canada)
FundersWellcome Trust
KeywordsEpidemiologyPublic healthEpidemiological surveillanceWork (physics)Political scienceEnvironmental healthMedicinePublic relationsEngineeringPathology

Abstract

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The increasing threat from infection with drug-resistant pathogens is among the most serious public health challenges of our time. Formed by Wellcome in 2018, the Surveillance and Epidemiology of Drug-Resistant Infections Consortium (SEDRIC) is an international think tank whose aim is to inform policy and change the way countries track, share, and analyse data relating to drug-resistant infections, by defining knowledge gaps and identifying barriers to the delivery of global surveillance. SEDRIC delivers its aims through discussions and analyses by world-leading scientists that result in recommendations and advocacy to Wellcome and others. As a result, SEDRIC has made key contributions in furthering global and national actions. Here, we look back at the work of the consortium between 2018-2024, highlighting notable successes. We provide specific examples where technical analyses and recommendations have helped to inform policy and funding priorities that will have real-world impact on the surveillance and epidemiology of infections with drug-resistant pathogens.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.114
metaresearch head score (Gemma)0.178
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.114
Threshold uncertainty score0.602

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.1140.178
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0060.006
Science and technology studies0.0040.007
Scholarly communication0.0210.010
Open science0.0030.014
Research integrity0.0050.008
Insufficient payload (model declined to judge)0.0080.004

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.094
GPT teacher head0.387
Teacher spread0.293 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes1
Has abstractyes

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