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Record W4406334399 · doi:10.1038/s43016-024-01089-5

Predictive equation derived from 6,497 doubly labelled water measurements enables the detection of erroneous self-reported energy intake

2025· article· en· W4406334399 on OpenAlexaff
Rania Bajunaid, Chaoqun Niu, Catherine Hambly, Zongfang Liu, Yosuke Yamada, Heliodoro Alemán-Mateo, Liam Anderson, Lenore Arab, Issad Baddou, Linda G. Bandini, Kweku Bedu-Addo, Ellen E. Blaak, Carlijn V. C. Bouten, Søren Brage, Maciej S. Buchowski, Nancy F. Butte, Stefan Gerardus Camps, Regina C. Casper, Graeme L. Close, Jamie A. Cooper, Richard Cooper, Sai Krupa Das, Peter S.W. Davies, Prasangi Dabare, Lara R. Dugas, Simon Eaton, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W. Fudge, Melanie B. Gillingham, Annelies Goris, Michael Gurven, Asmaa El Hamdouchi, Hinke Haisma, Daniël J. Hoffman, Marije B. Hoos, Sumei Hu, Noorjehan Joonas, Annemiek M. Joosen, Peter T. Katzmarzyk, Misaka Kimura, William E. Kraus, Wantanee Kriengsinyos, Rebecca Kuriyan, Robert F. Kushner, Estelle V. Lambert, Pulani Lanerolle, Christel Larsson, William R. Leonard, Nader Lessan, Marie Löf, Corby K. Martin, Eric Matsiko, Anine Christine Medin, James C. Morehen, James P. Morton, Aviva Must, Marian L. Neuhouser, Theresa A. Nicklas, Christine Delisle Nyström, Robert Ojiambo, Kirsi H. Pietiläinen, Yannis Pitsiladis, Jacob Plange‐Rhule, Guy Plasqui, Ross L. Prentice, Susan B. Racette, David A. Raichlen, Éric Ravussin, Leanne M. Redman, John J. Reilly, Rebecca M. Reynolds, Susan B. Roberts, Dulani Samaranayakem, Luís B. Sardinha, Analiza M. Silva, Anders Sjödin, Marina Stamatiou, Eric Stice, Samuel S. Urlacher, Ludo M. Van Etten, Edgar van Mil, George Wilson, Jack A. Yanovski, Tsukasa Yoshida, Xueying Zhang, Alexia J. Murphy‐Alford, Srishti Sinha, Cornelia Loechl, Amy Luke, Herman Pontzer, Jennifer Rood, Hiroyuki Sagayama, Dale A. Schoeller, Klaas R. Westerterp, William W. Wong, John R. Speakman

Bibliographic record

VenueNature Food · 2025
Typearticle
Languageen
FieldMedicine
TopicNutritional Studies and Diet
Canadian institutionsCanadian Institute for Advanced Research
FundersNational Institute of Diabetes and Digestive and Kidney DiseasesBureau of International Cooperation, Chinese Academy of SciencesInternational Atomic Energy AgencyChinese Academy of SciencesNational Science Foundation
KeywordsNational Health and Nutrition Examination SurveySpurious relationshipDoubly labeled waterStatisticsEnvironmental healthBody mass indexStructural equation modelingRegression analysisMathematicsMedicineDemographyEnergy expenditureEconometricsEndocrinology

Abstract

fetched live from OpenAlex

Nutritional epidemiology aims to link dietary exposures to chronic disease, but the instruments for evaluating dietary intake are inaccurate. One way to identify unreliable data and the sources of errors is to compare estimated intakes with the total energy expenditure (TEE). In this study, we used the International Atomic Energy Agency Doubly Labeled Water Database to derive a predictive equation for TEE using 6,497 measures of TEE in individuals aged 4 to 96 years. The resultant regression equation predicts expected TEE from easily acquired variables, such as body weight, age and sex, with 95% predictive limits that can be used to screen for misreporting by participants in dietary studies. We applied the equation to two large datasets (National Diet and Nutrition Survey and National Health and Nutrition Examination Survey) and found that the level of misreporting was >50%. The macronutrient composition from dietary reports in these studies was systematically biased as the level of misreporting increased, leading to potentially spurious associations between diet components and body mass index.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.007
metaresearch head score (Gemma)0.030
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.009
Threshold uncertainty score0.035

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0070.030
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0020.002
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0010.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.021
GPT teacher head0.247
Teacher spread0.226 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations46
Published2025
Admission routes1
Has abstractyes

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