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Extended‐Spectrum Beta‐Lactamase Testing for <i>Enterobacterales</i>

2023· other· en· W4406364995 on OpenAlexaff
Johann Pitout

Bibliographic record

VenueClinMicroNow · 2023
Typeother
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicAntibiotic Resistance in Bacteria
Canadian institutionsUniversity of Calgary
Fundersnot available
KeywordsSulbactamTazobactamBeta-lactamaseCephalosporinBroth microdilutionMicrobiologyChemistryBiologyAntibioticsAntibiotic resistanceMinimum inhibitory concentrationEscherichia coliImipenemBiochemistryGene

Abstract

fetched live from OpenAlex

Abstract The extended‐spectrum β‐lactamases (ESBLs) are enzymes that cause resistance to the oxyimino‐cephalosporins and the monobactams but not the cephamycins or the carbapenems. The detection of ESBLs involves a screening step followed by confirmation tests. ESBLs are inhibited by “classical“ β‐lactamase inhibitors such as clavulanic acid, sulbactam, and tazobactam. Laboratory tests for confirming ESBL‐producing bacteria are based on this property. The phenotypic ESBL confirmatory test can be performed by disk diffusion or by the broth microdilution MIC method. Commercially available ESBL gradient diffusion strips may also be used for ESBL confirmatory testing. The chapter covers proper quality control principles for analytical tests. With postanalytical considerations, it provides attention to common test limitations, interpretive challenges, and results reporting.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Other · Consensus signal: Other
Teacher disagreement score0.189
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.018
GPT teacher head0.276
Teacher spread0.258 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designNot applicable
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2023
Admission routes1
Has abstractyes

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