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Record W4406371079 · doi:10.1021/acs.jmedchem.4c02121

PET Imaging of Solid Tumors with a G-Quadruplex-Targeting <sup>18</sup>F-Labeled Peptide Probe

2025· article· en· W4406371079 on OpenAlexaff
Xiao‐Chun Guo, Dazhi Shi, Shun Huang, Yi-Han Zhang, Wanying Zhang, Jing Chen, Zebin Huang, Hubing Wu, Jinqiang Hou, Fujun Jin, Xiu‐Cai Chen, Wing‐Leung Wong, Yu‐Jing Lu

Bibliographic record

VenueJournal of Medicinal Chemistry · 2025
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicDNA and Nucleic Acid Chemistry
Canadian institutionsLakehead UniversityThunder Bay Regional Research Institute
FundersBasic and Applied Basic Research Foundation of Guangdong ProvinceGuangdong University of TechnologySouthern Medical UniversityGuangdong Science and Technology DepartmentNatural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of China
KeywordsIn vivoChemistryPositron emission tomographyPeptidePreclinical imagingMolecular imagingCancerComputational biologyCancer researchG-quadruplexDNABiophysicsBiochemistryNuclear medicineBiologyMedicineGenetics

Abstract

fetched live from OpenAlex

Bimetallic surfaces have been found to greatly improve the performance of numerous chemical processes due to synergistic interactions between the metal components. To be able to tailor the adsorption of aromatic molecules of these surfaces, the synergistic interactions within the surface and their effects on adsorbates must be elucidated. In this work, we examine the energetic and electronic interaction between benzene and several model PdFe bimetallic surfaces, with low and high Pd coverage limits, using density functional theory and compare our results with the adsorption of benzene on a pure Fe (110) surface. The adsorption energy trends on these model surfaces show that the interactions between the Pd and Fe significantly decrease the strength of benzene’s adsorption on surface Pd without significantly weakening its adsorption on the adjacent surface Fe. From the electronic analyses, the decreased adsorption strength of benzene on the model PdFe surfaces is due to the shift in the Pd’s d-band center away from the Fermi level. These results show that aromatic compounds will preferentially adsorb onto any exposed Fe in a PdFe surface due to the greater availability of electronic states near the Fermi level. Therefore, under typical catalytic conditions, the strength of the adsorption of benzene can be tailored on the basis of the amount of Pd added to an Fe surface because increasing the concentration of Pd in the surface will increase the amount of interaction between the adsorbate and the modified surface Pd.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.000
Threshold uncertainty score0.002

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.004
GPT teacher head0.246
Teacher spread0.241 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations7
Published2025
Admission routes1
Has abstractyes

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