Outcomes of ciclosporin treatment in paediatric patients with drug reaction with eosinophilia and systemic symptoms (DRESS): a retrospective cohort analysis
Why this work is in the frame
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Bibliographic record
Abstract
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but severe hypersensitivity reaction. In this retrospective cohort study, we compared the efficacy of systemic corticosteroids, the current first-line treatment, with ciclosporin, a treatment that is increasingly being used in paediatric patients with DRESS. We analysed the cases of 14 paediatric patients (aged < 18 years) admitted to the hospital between January 2016 and September 2023. Five patients received ciclosporin, while nine were treated with systemic corticosteroids. Ciclosporin treatment was associated with shorter hospital stays (median 6 days vs. 9 days) and more rapid normalization of alanine aminotransferase levels (25 days vs. 40 days) compared with corticosteroid treatment. While ciclosporin was well-tolerated, corticosteroid treatment was linked to adverse events, including corticosteroid-induced diabetes (n = 2), disease flares during tapering (n = 3) and the need for treatment intensification (n = 2). These findings suggest that ciclosporin may be a promising treatment for managing paediatric DRESS.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it