Filamin C Cardiomyopathy With Myocarditis in Childhood
Bibliographic record
Abstract
We present a case of a child presenting with recurrent myocarditis 5 years before developing dilated cardiomyopathy with a novel filamin C truncating variant.Complicated myocarditis in children is commonly caused by genetic cardiomyopathy.We recommend genetic testing for its provision of important diagnostic, prognostic, therapeutic, and reproductive risk information. CaseA previously healthy 14-year-old boy presented to hospital with acute pleuritic chest pain, which improved with nonsteroidal anti-inflammatory drug treatment.He had had a respiratory tract illness 3 months prior, no additional sick contacts, and no recent travel.There was no relevant past medical history.There was a family history of sudden cardiac death in 2 maternal uncles.Clinical examination showed blood pressure 106/73 mm Hg, heart rate 64 bpm, respiratory rate 16 bpm, and oxygen saturation 99% in room air.S1 and S2 heart sounds were normal.There were no extra heart sounds or murmurs.Filling pressures were normal.There was no peripheral edema.The respiratory examination was unremarkable.Laboratory testing found hemoglobin 168 g/L, leukocytes CJC Pediatric and Congenital Heart Disease 4 (2025) 170e172
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.003 | 0.002 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".