P0805 Sigmoidoscopy is sufficient as a surveillance tool in pediatric Ulcerative Colitis; full colonoscopy is not typically needed
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Abstract Background Sigmoidoscopy is a less invasive procedure than full colonoscopy, demands simpler preparation, requires shorter procedure time, and may be conducted with lighter sedation. Despite these advantages and the continuous nature of inflammation in ulcerative colitis (UC), which typically decreases from distal to proximal colon, the FDA recently requests full colonoscopy to assess UC in clinical trials (i.e. 3 colonoscopies in 54 weeks). Data to support this requirement are scarce in children. We, thus, aimed to assess the necessity of full colonoscopy versus limited sigmoidoscopy in pediatric UC. Methods We included two prospectively enrolled cohorts of children (0-18 years) with UC, both with identical data collection relevant to this study: one from a single-center prospective registry, and the other from a prospective validation of the TUMMY-UC, a patient-reported signs and symptoms for pediatric UC. In addition to explicit clinical, disease activity, labs and demographic data, the Ulcerative Colitis Endoscopic Index of Severity (UCEIS) was recorded prospectively for each colonic segment. The first colonoscopy available after the time of diagnosis was included to better mirror the scenario of post-treatment follow-up monitoring, since the diagnostic procedure should always be full colonoscopy. Results A total of 85 patients were included (mean age 14 ± 3.4, 11 [13%] with endoscopic healing, 45 [53%] with mild colitis and 29 [34%] with moderate-severe colitis). The median UCEIS scores decreased progressively from the rectum and sigmoid (2, IQR:0-4) to the more proximal colon (descending 1, IQR:0-3; transverse and ascending 0, IQR:0-2; p < 0.001). Only 3 patients (3.5%) had inflammation in proximal segments without having inflammation in the rectosigmoid region. Another 10 patients (12%) had higher inflammation scores in the proximal colon than in the rectosigmoid (i.e. reverse gradient), though inflammation was still present in the rectosigmoid region. Conclusion In 96.5% of cases, endoscopic healing in the rectosigmoid region reflected endoscopic healing in the entire colon in children with UC. When inflammation was present in the rectosigmoid, in 86% the degree of colitis reflected the maximal endoscopic severity of the entire colon. These findings suggest that sigmoidoscopy may be a suitable routine post-treatment surveillance tool for pediatric UC patients and in the research setting in order to maximize feasibility and ethical considerations of clinical trials.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it