P0354 Mild cognitive impairment occurs in patients with inflammatory bowel disease irrespective of disease activity
Bibliographic record
Abstract
Abstract Background Inflammatory bowel disease (IBD) has been linked to a heightened risk of mood, behavioral, and neurological disorders. Limited research has focused on cognitive function in these patients, with inconsistent findings. We aimed to assess mild cognitive impairment in IBD patients compared to healthy controls (HC) matched for age, sex, and education. Methods This single-center observational study included adult IBD patients. Demographic and clinical data were collected. Clinical remission was defined as a Harvey-Bradshaw Index <5 for Crohn’s disease (CD) and a Partial Mayo Score <2 for ulcerative colitis (UC). Healthy controls were recruited from friends and relatives of the physicians involved in the study. Exclusion criteria included psychiatric or neurological disorders, language barriers, sleep disturbances, previous surgery, significant comorbidities, alcohol abuse, and use of steroids or other neuropsychologically active medications within 3 months before enrollment. Cognitive function was assessed by the Montreal Cognitive Assessment (MoCA), with a score >26 considered normal. Anxiety and depression were screened using the Hospital Anxiety and Depression Scale (HADS). Statistical analyses included the Mann-Whitney rank-sum or t-test for continuous variables and the Chi-square or Fisher’s exact test for categorical variables. Multiple logistic regression was employed to identify baseline clinical-psychometric factors associated with abnormal MoCA scores. Results A total of 112 IBD patients (57 CD and 55 UC) and 68 HC were enrolled. No significant differences were observed between IBD patients and HC regarding sex (p=0.231), age (p=0.248), or education (p=0.267). A significantly higher proportion of IBD patients had a pathological MoCA compared to HC (58% vs. 41%, p=0.033), even after excluding individuals with probable anxiety or depression as identified by HADS (46% vs. 24%, p=0.021). UC patients scored lower in the memory domain than HC (mean score 2.4 vs. 3.2, p=0.041). Factors associated with a pathological MoCA included age (p=0.032), education (p=0.002), and UC (p=0.034). In multivariate analysis, age (OR 1.04, 95% CI 1-1.1, p=0.015) and UC (OR 2.2, 95% CI 1.4-5.3, p=0.039) emerged as independent predictors of a pathological MoCA. Conclusion IBD patients exhibited a significantly higher prevalence of mild cognitive impairment compared to controls, as measured by the MoCA. Specifically, UC patients demonstrated impairments in the memory domain. Our findings support the concept of a gut-brain axis and suggest that colonic, rather than small bowel inflammation may play a role in the development of cognitive impairment in IBD. A multidisciplinary approach to IBD management should incorporate cognitive function assessment.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".