Fabrication of <scp>pH</scp> ‐sensitive bacterial cellulose/carboxymethyl cellulose hybrid hydrogel beads in agitated culture for oral drug delivery
Bibliographic record
Abstract
Abstract Bacterial cellulose (BC), a biopolymer with unique properties, has been employed in numerous biomedical applications. Carboxymethyl cellulose was introduced to the agitated culture of Gluconacetobacter xylinus to produce pH‐responsive BC hydrogel beads. It was shown by x‐ray diffraction (XRD) analysis that adding carboxymethyl cellulose to the agitated culture increased the crystallinity of the hydrogel beads. Scanning electron microscopy exhibited the 3‐D porous structure of microfibrils and the reverse effect of adding carboxymethyl cellulose on the hydrogels' porosity. The hydrogels were loaded with ibuprofen sodium salt (IbuNa), and their release and swelling studies were conducted in the simulated gastric and simulated intestinal fluids. It was observed that by increasing the amount of carboxymethyl cellulose in the culture medium, the pH responsivity of the beads was increased. Thus, this study shows the potential of the BC/CMC system as an oral drug delivery system.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".