Effects of daylong exposure to indoor overheating on enterocyte damage and inflammatory responses in older adults: a randomized crossover trial
Bibliographic record
Abstract
We evaluated enterocyte damage (IFABP), immune activation (sCD14), and inflammatory responses (TNF-α, IL-6, CRP) in 16 older adults (66–78 years) during 8 h rest in conditions simulating homes maintained at 22 °C (control), the 26 °C indoor temperature upper limit proposed by health agencies, and homes without air-conditioning during heatwaves (31 °C, 36 °C). Relative to 22 °C, IFABP was elevated ∼181 pg/mL after exposure to 31 °C ( P = 0.07), and by ∼378 pg/mL ( P < 0.001) after exposure to 36 °C. No differences were observed for sCD14, TNF-α, IL-6, or CRP (all P ≥ 0.26). Our data support recommendations to maintain indoor temperatures ≤ 26 °C to preserve gastrointestinal barrier integrity in heat-vulnerable persons.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.002 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.003 | 0.002 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.003 | 0.002 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".