The effects of L-thyroxine and its association with physical exercise decrease the inflammation in an acute lung injury model
Bibliographic record
Abstract
Acute lung injury (ALI) is an inflammatory disease with a high incidence and prevalence that can lead to death. While L-thyroxine is widely used as a synthetic hormone in the treatment of hypothyroidism, its effects on inflammatory processes are not fully understood. Physical exercise, recommended for the general population, serves as an ally in treating various pathologies. Due to this and the lack of understanding of how L-thyroxine affects the immune response, coupled with the well-known benefits of exercise, this study aimed to evaluate L-thyroxine’s effects on lipopolysaccharide-induced inflammation and its combination with exercise in ALI. We assessed L-thyroxine’s effects on RAW 264.7 cells exposed to LPS and its association with exercise in a mouse ALI model. Pre-treatment with L-thyroxine demonstrated a decrease in the production of reactive oxygen species ( P < 0.01) and the expression of pro-inflammatory genes and proteins ( P < 0.05). In ALI, pre-treatment with L-thyroxine, either alone or combined with exercise, reduced the cell influx ( P < 0.01) and the release of inflammatory cytokines ( P < 0.05), in addition to mitigating lung damage caused by LPS ( P < 0.01). However, combining L-thyroxine with exercise did not enhance its anti-inflammatory effect.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".