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Record W4406863120 · doi:10.1093/brain/awaf022

White matter connections within the central sulcus subserving the somato-cognitive action network

2025· article· en· W4406863120 on OpenAlexaff
Georgios P. Skandalakis, Luca Viganò, Clemens Neudorfer, Marco Rossi, Luca Fornia, Gabriella Cerri, Kelsey P Kinsman, Zabiullah Bajouri, Armin D. Tavakkoli, Christos Koutsarnakis, Evgenia Lani, Spyridon Komaitis, George Stranjalis, Gelareh Zadeh, Jessica Barrios‐Martinez, Fang‐Cheng Yeh, Demitre Serletis, Michael Kogan, Costas G. Hadjipanayis, Jennifer Hong, Nathan E. Simmons, Evan M. Gordon, Nico U.F. Dosenbach, Andreas Horn, Lorenzo Bello, Aristotelis Kalyvas, Linton T. Evans

Bibliographic record

VenueBrain · 2025
Typearticle
Languageen
FieldNeuroscience
TopicFunctional Brain Connectivity Studies
Canadian institutionsUniversity of Toronto
FundersIntellectual and Developmental Disabilities Research Center, Washington University School of Medicine in St. LouisNational Institute of Neurological Disorders and StrokeNational Institutes of HealthDeutsches Zentrum für Luft- und RaumfahrtHope Center for Neurological DisordersDeutsche ForschungsgemeinschaftIntellectual and Developmental Disabilities Research CenterNew Venture FundEU Joint Programme – Neurodegenerative Disease Research
KeywordsNeuroscienceCognitionCentral sulcusPsychologyWhite matterSulcusCortex (anatomy)Action (physics)Motor cortexStimulationMedicineMagnetic resonance imaging

Abstract

fetched live from OpenAlex

The somato-cognitive action network (SCAN) consists of three nodes interspersed within Penfield's motor effector regions. The configuration of the somato-cognitive action network nodes resembles the one of the 'plis de passage' of the central sulcus: small gyri bridging the precentral and postcentral gyri. Thus, we hypothesize that these may provide a structural substrate of the somato-cognitive action network. Using microdissections of 16 human hemispheres, we consistently identified a chain of three distinct plis de passage with increased underlying white matter in locations analogous to the somato-cognitive action network nodes. We mapped localizations of plis de passage into standard stereotactic space to seed functional MRI connectivity across 9000 resting-state functional MRI scans, which demonstrated the connectivity of these sites with the somato-cognitive action network. Intraoperative recordings during direct electrical central sulcus stimulation further identified inter-effector regions corresponding to plis de passage locations. This work provides a critical step towards an improved understanding of the somato-cognitive action network in both structural and functional terms. Furthermore, our work has the potential to guide the development of refined motor cortex stimulation techniques for treating brain disorders and operative resective techniques for complex surgery of the motor cortex.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.005
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesScience and technology studies
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.716
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.005
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0020.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.035
GPT teacher head0.278
Teacher spread0.243 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations14
Published2025
Admission routes1
Has abstractyes

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