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Record W4406894312 · doi:10.36838/v6i7.17

Glioblastoma Multiforme: A Review of the Genetic Alterations

2024· review· en· W4406894312 on OpenAlexaff
Sivani Edpuganti

Bibliographic record

VenueInternational journal of high school research · 2024
Typereview
Languageen
FieldMedicine
TopicGlioma Diagnosis and Treatment
Canadian institutionsEagle Ridge Hospital
Fundersnot available
KeywordsGlioblastomaMedicineBiologyCancer research

Abstract

fetched live from OpenAlex

Glioblastoma Multiforme is a neurological disease resulting from many genetic mutations.In the presence of Glioblastoma Multiforme patients are presented with a short period after their prognosis as this form of glioma is a stage 4 tumor, and it is also considered the most defective of the neurological tumors.This review article examines the multiple genetic alterations that occur because of the uncontrollable reproduction of the glioblastoma multiforme tumor cells in the nervous system.Previous experiences and studies discussed singular gene mutations in Glioblastoma Multiforme.However, the reason these specific mutations occur, their advantages for the disease, and the normal function of the unmutated genes still need to be fully uncovered.In my review article, I found that Glioblastoma Multiforme is a very invasive form of cancer that occurs because of many genetic mutations.The mutations will also provide information about potential therapeutic strategies to eradicate the disease from patients.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.004
Threshold uncertainty score0.013

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0040.004
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0010.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0040.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.090
GPT teacher head0.481
Teacher spread0.390 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2024
Admission routes1
Has abstractyes

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