P-576. Real-world Experience with the Two-Drug Regimen Dolutegravir/Lamivudine for the Treatment of HIV-1 among Vulnerable People Living with HIV in Canada: Preliminary Results from a Chart Review Study
Bibliographic record
Abstract
Abstract Background Compared to the general population of people living with HIV, vulnerable people, such as those who use drugs, are disproportionately affected by HIV, and are predisposed to lower adherence to antiretroviral therapies (ARTs), which may result in poorer virologic suppression, worse health outcomes, and higher HIV transmission rates. Some may benefit from simpler single-tablet regimens that are effective, well tolerated, and limit exposure to unnecessary medications. We evaluated clinical outcomes in vulnerable people living with HIV who switched to the single-tablet, 2-drug regimen dolutegravir/lamivudine (DTG/3TC). Methods This ongoing chart review study included people living with HIV (≥ 18 years) in Canada who switched to DTG/3TC between 09/09/2019 and 31/05/2023, and had ≥ 1 of the following vulnerability criteria: recent drug use, opioid agonist use, recent or well-documented history of unstable housing or receiving social assistance, Indigenous identity, or ≥ 65 years of age with diminished autonomy (‘vulnerable senior’). Descriptive summary statistics were generated for demographic and clinical characteristics at baseline (≤ 12 months pre-switch), and viral load and CD4+ cell counts at 6 (± 2) and 12 (± 2) months post-switch. Interim results are reported for the ongoing study. Results Across 5 sites, 20 eligible people were included (mean age: 49.9 ± 13.0 years; male: 80%; drug use: 80%; vulnerable senior: 20%). Simplification of ART was the predominant reason for switch to DTG/3TC (n=11, 55%). At the time of analysis, 80% (n=16) had at least 6 months of follow-up, and one discontinued DTG/3TC due to intolerance. At 6 months, of those with test results, 8/8 were virally suppressed (< 50 c/mL), and median (IQR) CD4+ cell count was 815 (122.5) cells/mm3. At 12 months, 11/12 were virally suppressed (< 50 c/mL), and median CD4+ cell count was 920 (180) cells/mm3 (n=10). Conclusion Preliminary results suggest promising effectiveness outcomes among vulnerable people living with HIV who switch to DTG/3TC. These results support the continued expansion of this study to include more people. Disclosures Emmanuelle Huchet, MD, AbbVie: Honoraria|Gilead Sciences: Advisor/Consultant|Gilead Sciences: Honoraria|Indivior: Advisor/Consultant|ViiV Healthcare: Advisor/Consultant Joann K. Ban, PharmD, MSc, GSK: employee Adenike R. Adelakun, BPharm, MSc, GSK: employee Katherine Osenenko, MCPM, Broadstreet HEOR: employee|ViiV Healthcare: Funding for the conduct of this work Isabelle Hardy, PhD, ViiV Healthcare: employee Elaine Stewart, HBSc, ViiV Healthcare: employee Michael McKimm, BSc, ViiV Healthcare: employee Jean-Francois Fortin, MD, ViiV Healthcare: employee Madeleine Crabtree, MPH, Broadstreet HEOR: employee|ViiV Healthcare: Funding for the conduct of this work Karissa Johnston, MSc, PhD, Broadstreet HEOR: employee|ViiV Healthcare: Funding for the conduct of this work Brian Conway, MD, AbbVie: Advisor/Consultant|AbbVie: Grant/Research Support|AbbVie: Honoraria|AstraZeneca: Advisor/Consultant|AstraZeneca: Grant/Research Support|AstraZeneca: Honoraria|Gilead Sciences: Advisor/Consultant|Gilead Sciences: Grant/Research Support|Gilead Sciences: Honoraria|GSK: Advisor/Consultant|GSK: Grant/Research Support|GSK: Honoraria|Indivior Canada: Advisor/Consultant|Indivior Canada: Grant/Research Support|Indivior Canada: Honoraria|Merck: Advisor/Consultant|Merck: Grant/Research Support|Merck: Honoraria|Moderna: Advisor/Consultant|Moderna: Grant/Research Support|Moderna: Honoraria|Sanofi Pasteur: Advisor/Consultant|Sanofi Pasteur: Grant/Research Support|Sanofi Pasteur: Honoraria|Seqirus: Advisor/Consultant|Seqirus: Grant/Research Support|Seqirus: Honoraria|ViiV Healthcare: Advisor/Consultant|ViiV Healthcare: Grant/Research Support|ViiV Healthcare: Honoraria V. Paul DiMondi, PharmD, GSK: Stocks/Bonds (Public Company)|ViiV Healthcare: Employee
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.012 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.002 | 0.003 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".