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Record W4406999863 · doi:10.1016/j.xfre.2025.01.018

The phenomenon of explaining the cause of poor cycle outcomes: looking under the streetlight, or the role of cognitive bias in Reproductive Endocrinology and Infertility practices. In response to: “Unexpected poor oocyte retrieval: the phenomenon of the borderline response to the Gonadotropin-Releasing Hormone (GnRH) agonist trigger”

2025· article· en· W4406999863 on OpenAlexaff
Jennia Michaeli, Heather Shapiro

Bibliographic record

VenueF&S Reports · 2025
Typearticle
Languageen
FieldMedicine
TopicOvarian function and disorders
Canadian institutionsSinai Health SystemUniversity of Toronto
Fundersnot available
KeywordsPhenomenonInfertilityReproductive EndocrinologyOocyteCognitionPsychologyFertilityGynecologyDevelopmental psychologyMedicineInternal medicineBiologyPsychiatryPregnancyEnvironmental healthHormonePhysics

Abstract

fetched live from OpenAlex

We read with great interest the editorial about borderline response (1), defined in part as poor oocyte yield and/or low oocyte maturity in in vitro fertilization cycles triggered with gonadotropin-releasing hormone (GnRH) agonist. Understandably, such cycle outcomes are upsetting to patients and caregivers alike and lead to an immediate search for a culprit. However, the GnRH agonist trigger may be inferior to the human chorionic gonadotropin (hCG) trigger in eliciting full nuclear and cytoplasmic maturation of the oocyte and further follicular disintegration, thus causing faulty final follicular maturation or oocyte retrieval failure.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.006
metaresearch head score (Gemma)0.040
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.757
Threshold uncertainty score0.968

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0060.040
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.002
Science and technology studies0.0010.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.032
GPT teacher head0.328
Teacher spread0.296 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes1
Has abstractyes

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