Sleep duration, physical activity and cardiometabolic multimorbidity: Findings from the English Longitudinal Study of Ageing
Bibliographic record
Abstract
Abstract Background U-shaped relationships have been demonstrated between sleep duration and several cardiometabolic conditions. However, the association between sleep duration and cardiometabolic multimorbidity (CMM) and the interrelationship with physical activity has not been previously investigated. We aimed to assess the prospective associations of sleep habits (duration and quality) with CMM and the interplay with physical activity. Methods and Results We included 3,428 participants (mean age 63 years at baseline, 44.8% male) free of hypertension, coronary heart disease, diabetes, and stroke at wave 4 from the English Longitudinal Study of Ageing. Sleep habits were assessed by self-reports. Cardiometabolic multimorbidity was defined as the presence of at least two multiple long-term conditions (hypertension, cardiovascular disease, diabetes, and stroke) at wave 10. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated using logistic regression models adjusted for established cardiometabolic risk factors including physical activity. At 15 years follow-up, 206 participants developed CMM. There was an approximate U-shaped trend between sleep duration and the risk of CMM. Compared to participants with sleep duration of 7-8 hrs/day, the multivariable OR (95% CI) for CMM was 1.39 (1.03-1.90) for sleep duration ≤6 hrs/day and 1.05 (0.55-2.00) for sleep duration ≥ 9 hrs/day. The odds of CMM modestly decreased for each additional hour increase in sleep duration in participants with sleep duration ≤6 hrs/day (OR, 0.78, 95% CI: 0.59-1.02). Sleep quality or physical activity was not associated with CMM. Conclusions Short sleep duration is associated with an increased risk of CMM, which is independent of established cardiometabolic risk factors including physical activity. Importantly, each additional hour of sleep among those with short sleep durations appeared to mitigate CMM risk, underscoring the potential benefits of optimizing sleep duration.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.004 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".