CYCLIC VARIATIONS OF CORTISOL, TRIIODOTYRONINE (T3) AND TYROXINE (T4) ON BEFORE AND AFTER PARTURITION OF QUARTER HORSE MARES VARIAÇÕES CÍCLICAS DO CORTISOL, TRIIODOTIRONINA (T3) E TIROXINA (T4) NO PERIPARTO DE ÉGUAS DA RAÇA QUARTO DE MILHA
Bibliographic record
Abstract
This study was designed to evaluate changes in plasma concentrations of cortisol (Cs), triiodothyronine (T3) and thyroxine (T4), as well as their circadian rhythm during peripartal period of Quarter Horse mares. Eighteen clinically healthy mares, with age between 60 and 96 months and alive weight (AW) between 350 and 420 Kg were divided in three groups (n=6) according the reproductive status, that means: no pregnant (TE), Pregnant (GE) and after parturition (PA).The blood samples were taken during 24 hours in intervals of two hours.There was no differences between cortisol levels regarding the reproductive status and periods of blood samples collections. This hormone showed a circadian rhythm, with accentuated oscillation in TE, but small for GE and PA. For T3 and T4 there was difference between reproductive status (P<0.05 and P<0.01), respectively, as well as for the periods (P<0.01 and P<0.05), respectively. It was possible to characterize the circadian rhythm for both hormones, verifying great oscillation for T3 in PA in the morning. It was possible to conclude that the final phase of pregnancy alter cortisol , T3 and T4 secretion standards, keeping, however, the rhythm, suggesting an organism adaptation along the peripartal period. KEY WORDS: Equine, reproductive status, hormones, circadian rhythm. O objetivo deste estudo foi verificar as alterações nas concentrações plasmáticas e o ritmo circadiano do cortisol (Cs), triiodotironina (T3) e tiroxina (T4) no periparto de éguas da raça quarto de milha. Utilizaram-se dezoito éguas clinicamente sadias, com idade entre 60 e 96 meses e peso vivo (PV) entre 350 e 420 Kg, divididas em três grupos (n=6), de acordo com o estágio reprodutivo: * vazias (TE), gestantes (GE) e paridas (PA). As amostras de sangue foram colhidas durante 24 horas em intervalos de duas horas. Para o cortisol, não houve diferença entre os estágios reprodutivos nos períodos avaliados. Verificou-se a ocorrência de ritmo circadiano para este hormônio, com oscilação acentuada em GE, e menor em TE e PA. Para T3 e T4, houve diferença entre o estágio reprodutivo (P<0,05 e P<0,01, respectivamente), assim como para os períodos observados (P<0,01 e P<0,05, respectivamente). Foi possível caracterizar o ritmo circadiano para os dois hormônios tireoideanos, verificando-se maiores oscilações para T3 em PA no início da manhã. Com base nestes achados, conclui-se que a fase final da gestação altera os padrões de secreção do cortisol, de T3 e T4, mantendo-se, porém, o ritmo, sugerindo adaptação do organismo ao longo do período periparto. PALAVRAS-CHAVES: Eqüinos, estágio reprodutivo, hormônios, ritmo circadiano.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".