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Novel Delivery Approaches and Therapeutic Potential of Resveratrol – AReview

2025· review· en· W4407147234 on OpenAlexaff
Zulfa Nooreen, Awani Kumar, Pranay Wal, Manish R. Bhise, Jadhav Balaji, Amin Gasmi

Bibliographic record

VenueCurrent Chemical Biology · 2025
Typereview
Languageen
FieldMedicine
TopicSirtuins and Resveratrol in Medicine
Canadian institutionsNutrition International
Fundersnot available
KeywordsResveratrolPharmacologyMedicine

Abstract

fetched live from OpenAlex

Abstract: Resveratrol (RV) is a well-known polyphenolic compound found in many different plants, including the fruits of grape, peanut, and berry trees. It is well-known for its links to a number of health benefits, including those related to glucose metabolism, anti-aging, anti-tumor, antiobesity, anticancer and neuroprotective effects. Promising therapeutic properties have been reported in multiple cancers, neurodegenerative diseases, and atherosclerosis. These properties are regulated by multiple synergistic pathways that govern inflammation, oxidative stress, and cell death. RV also has a potent anti-adipogenic effect by preventing fat accumulation and triggering lipolytic and oxidative pathways. By preventing platelet aggregation, it demonstrates its cardioprotective properties. RV also has a potent anti-adipogenic effect by preventing fat accumulation and triggering lipolytic and oxidative pathways. By preventing platelet aggregation, it demonstrates its cardioprotective properties.To increase resveratrol's dissolution, stability, oral bioavailability, and regulated evacuation, nanotechnologies have become widely used.RV's drug-delivery methods linked to bioavailability have additionally been extensively utilised, and RV nanoparticles and liposomes seem to be viable platforms for improving their bioavailability. The current review seeks to give an organised summary of the medicinal advantages and recent discoveries.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.004
Threshold uncertainty score0.012

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0000.000
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0040.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.116
GPT teacher head0.371
Teacher spread0.255 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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