CsCF3B(OMe)3: A Versatile Nucleophilic Source of the Trifluoromethyl Anion
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Abstract We have identified cesium trimethoxy(trifluoromethyl)borate [CsCF3B(OMe)3] as a nucleophilic source for the trifluoromethylation of carbonyl compounds. A differentiating characteristic of CsCF3B(OMe)3 is its heightened reactivity in ethereal solvents compared to its potassium analogue, which is typically employed in dimethylformamide. Also, in contrast to the extensively studied Ruppert–Prakash reagent (TMSCF3), CsCF3B(OMe)3 does not require the addition of an exogenous activator. Described herein, we detail the synthesis of CsCF3B(OMe)3 and demonstrate its efficacy in trifluoromethylation across various scaffolds, including methyl ketones, isatin derivatives, and 1,2-acyclic dicarbonyls.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it