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Record W4407173730 · doi:10.1136/bmj-2024-081554

FUTURE-AI: international consensus guideline for trustworthy and deployable artificial intelligence in healthcare

2025· article· en· W4407173730 on OpenAlexfundno aff
Karim Lekadir, Alejandro F. Frangi, Antonio R. Porras, Ben Glocker, Celia Cintas, Curtis P. Langlotz, Eva Weicken, Folkert W. Asselbergs, Fred Prior, Gary S. Collins, Georgios Kaissis, Gianna Tsakou, Irène Buvat, Jayashree Kalpathy-Cramer, John Mongan, Julia A. Schnabel, Kaisar Kushibar, Katrine Riklund, Kostas Marias, Lameck Mbangula Amugongo, Lauren A. Fromont, Leonor Cerdá-Alberich, Luis Martí‐Bonmatí, M. Jorge Cardoso, Maciej Bobowicz, Mahsa Shabani, Manolis Tsiknakis, María A. Zuluaga, Marie-Christine Fritzsche, Marina Camacho, Marius George Linguraru, Markus Wenzel, Marleen de Bruijne, Martin G. Tolsgaard, Melanie Goisauf, Mónica Cano Abadía, Noussair Lazrak, Oriol Pujol, Richard Osuala, Sandy Napel, Sara Colantonio, Smriti Joshi, Stefan Klein, Susanna Aussó, Wendy Rogers, Zohaib Salahuddin, Martijn P. A. Starmans

Bibliographic record

VenueBMJ · 2025
Typearticle
Languageen
FieldMedicine
TopicArtificial Intelligence in Healthcare and Education
Canadian institutionsnot available
FundersNational Institute of Biomedical Imaging and BioengineeringFogarty International CenterNational Heart, Lung, and Blood InstituteInstituto de Salud Carlos IIIMedical Research CouncilInstitute for Information and Communications Technology PromotionNatural Sciences and Engineering Research Council of CanadaCentre National de la Recherche ScientifiqueCancer Research UKWellcome TrustKWF KankerbestrijdingNational Health and Medical Research CouncilMinistério da Ciência, Tecnologia e InovaçãoConselho Nacional de Desenvolvimento Científico e TecnológicoNational Natural Science Foundation of ChinaEuropean Regional Development FundEuropean CommissionHORIZON EUROPE Framework ProgrammeNederlandse Organisatie voor Wetenschappelijk OnderzoekAgence Nationale de la RechercheAgencia Nacional de Investigación y DesarrolloAgency for Science, Technology and ResearchGordon and Betty Moore FoundationMinisterio de Ciencia, Innovación y UniversidadesNational Institutes of HealthH2020 HealthRoyal Academy of EngineeringNational Institute for Health and Care Research
KeywordsTrustworthinessGuidelineComputer scienceHealth careArtificial intelligenceConsensus conferenceComputer securityMedicinePolitical scienceLibrary sciencePathologyLaw

Abstract

fetched live from OpenAlex

Despite major advances in artificial intelligence (AI) research for healthcare, the deployment and adoption of AI technologies remain limited in clinical practice. This paper describes the FUTURE-AI framework, which provides guidance for the development and deployment of trustworthy AI tools in healthcare. The FUTURE-AI Consortium was founded in 2021 and comprises 117 interdisciplinary experts from 50 countries representing all continents, including AI scientists, clinical researchers, biomedical ethicists, and social scientists. Over a two year period, the FUTURE-AI guideline was established through consensus based on six guiding principles—fairness, universality, traceability, usability, robustness, and explainability. To operationalise trustworthy AI in healthcare, a set of 30 best practices were defined, addressing technical, clinical, socioethical, and legal dimensions. The recommendations cover the entire lifecycle of healthcare AI, from design, development, and validation to regulation, deployment, and monitoring.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.120
metaresearch head score (Gemma)0.157
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Methods · Consensus signal: none
Teacher disagreement score0.120
Threshold uncertainty score0.633

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.1200.157
Meta-epidemiology (narrow)0.0030.002
Meta-epidemiology (broad)0.0040.011
Bibliometrics0.0120.008
Science and technology studies0.0040.008
Scholarly communication0.0110.009
Open science0.0170.014
Research integrity0.0340.026
Insufficient payload (model declined to judge)0.0040.006

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.119
GPT teacher head0.479
Teacher spread0.360 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations348
Published2025
Admission routes1
Has abstractyes

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Same venueBMJSame topicArtificial Intelligence in Healthcare and EducationFrench-language works237,207