A208 MENTAL HEALTH, WORK IMPAIRMENT, AND MEDICATION SATISFACTION AMONGST INDIVIDUALS WITH INFLAMMATORY BOWEL DISEASE RECEIVING LONG-TERM BIOLOGIC AND ADVANCED TREATMENT
Bibliographic record
Abstract
Abstract Background Biologic and advanced immunotherapies have been shown to be effective in controlling biochemical, endoscopic, and histologic disease activity in individuals with Inflammatory Bowel Disease (IBD). However, there is limited data assessing the prevalence of somatic symptoms, mental health, and quality of life (QoL) in this population. To provide holistic care and appropriately manage both gut and somatic symptoms, it is critical to assess the prevalence of these symptoms and impairments. Aims This study assessed the prevalence of mental health deficits, quality of life, and work impairment in IBD patients who are being treated with biologic and advanced therapies for at least six months. The objective was to assess whether significant gaps in these domains persist as well as whether individuals are satisfied with their current advanced treatment. Methods Cross-sectional data was prospectively collected using a survey completed by individuals >18 years old, with a known diagnosis of Ulcerative Colitis, Crohn’s Disease, or Indeterminate Colitis, who have been receiving a biologic or advanced immunotherapy at a stable dose for >= 6 months. In addition to demographic data, the survey contained validated questionnaires assessing mental health, work impairment, and QoL. The presence of deficits in these domains was then evaluated using absolute scores and validated cutoffs. Results This study included 37 individuals who completed the survey as well as an additional 3 who completed part of it. 85% of respondents agreed that their current therapy has improved their symptoms and 62.5% of respondents are satisfied with their current treatment. 5.4-29.7% and 13.5-29.7% endorsed symptoms consistent with depression and anxiety respectively on different questionnaires. 51.4% of respondents endorsed active symptoms, and 56.8% endorsed symptom severity consistent with non-remission. A mean of 2.74 hours of weekly work productivity were lost due to IBD activity. Conclusions The majority of individuals with IBD on long-term advanced therapy report symptom improvement and satisfaction with their treatment. However, more than half endorsed ongoing symptoms of IBD, including work impairment, and nearly one-third endorsed mental health impairment consistent with depression or anxiety. This suggests that despite perceived treatment efficacy, significant gaps in these domains persist. Funding Agencies None
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".