Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Introduo: A sndrome de Down a causa mais frequente de deficincia intelectual de origem gentica.Pessoas com Sndrome de Down (SD) possuem altas chances de desenvolver a Doena de Alzheimer (DA) de modo precoce, antes dos 40 anos.Objetivo: Relacionar a SD com a DA, buscando entender a fisiopatologia da ligao de ambas doenas com possveis prevenes.Metodologia: Trata-se de uma reviso de literatura com referncias da base de dados do "PubMed".Foram utilizados Descritores em Cincia da Sade (DECS) na lngua inglesa e os operadores booleanos: "Alzheimer Disease" AND "Early " AND "Down Syndrome" AND "Prevention".Foram filtradas 11 publicaes correspondentes do ano de 2020 ao ano de 2024 e, destas, 8 foram selecionadas para a leitura completa.Resultados: A trissomia do cromossomo 21 est relacionada com baixos nveis do gene dos genes APP e DYRK1A, o que leva a uma superproduo da protena beta-amiloide (A) e, consequentemente, uma neuroinflamao.Essa, por sua vez, faz uma contribuio significativa para o desenvolvimento de demncia associada DA.Na literatura, foram encontradas algumas sugestes de mtodos que possam prevenir o desenvolvimento da DA na SD.Nesse sentido, tanto a inibio do DYRK1A quanto a imunizao materna com antgenos anti-A conseguem servir para interromper os efeitos fenotpicos da superexpresso de A.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.011 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it