Characterization of three native Streptomyces isolates that inhibit the growth of fluconazole-resistant Candida spp strains.
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Most fungal infections are caused by species of the Candida genus, particularly C. albicans. The increasing number of strains developing resistance to antifungals, resulting in treatment failures, underscores the urgency of finding new antifungal agents. Since many bacteria of the genus Streptomyces produce molecules that inhibit fungal growth, this work aimed to evaluate the antifungal activity of three native isolates obtained from a rhizosphere and an artisanal composting system. Based on 16S RNA gene sequences, as well as biochemical and morphological traits, we identified S. globisporus, S. bacillaris, and S. cavourensis as the species most closely related to the S1H, S40, and S41 isolates, respectively. These species have been reported to produce antifungal compounds. Theinhibition of Candida by antagonistic activity increased with longer Streptomyces incubation times, with no differences observed between Candida species. Few studies have simultaneously evaluated the inhibitory activity of Streptomyces isolates against different Candida strains. In this study, the isolates inhibited the growth of C. albicans, C. krusei, C. guilliermondii, C. glabrata, and C. lusitaniae, including strains resistant to fluconazole.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it