Support Vector Machine for Stratification of Cognitive Impairment Using 3D T1WI in Patients with Type 2 Diabetes Mellitus
Bibliographic record
Abstract
Purpose: To explore the potential of MRI-based radiomics in predicting cognitive dysfunction in patients with diagnosed type 2 diabetes mellitus (T2DM). Patients and Methods: In this study, data on 158 patients with T2DM were retrospectively collected between September 2019 and December 2020. The participants were categorized into a normal cognitive function (N) group (n=30), a mild cognitive impairment (MCI) group (n=90), and a dementia (DM) group (n=38) according to the Chinese version of the Montréal Cognitive Assessment Scale-B (MoCA-B). Radiomics features were extracted from the brain tissue except ventricles and sulci in the 3D T1WI images, support vector machine (SVM) model was then established to identify the CI and N groups, and the MCI and DM groups, respectively. The models were evaluated based on their area under the receiver operating characteristic curve (AUC), Precision (P), Recall rate (Recall, R), F1-score, and Support. Finally, ROC curves were plotted for each model. Results: The study consisted of 68 cases in the N and CI group, with 54 cases in the training set and 14 in the verification set, and 128 cases were included in the MCI and DM groups, with 90 training sets and 38 verification sets. The consistency for inter-group and intra-group of radiomics features in two physicians were 0.86 and 0.90, respectively. After features selection, there were 11 optimal features to distinguish N and CI and 12 optimal features to MCI and DM. In the test set, the AUC for the SVM classifier was 0.857 and the accuracy was 0.830 in distinguishing CI and N, while AUC was 0.821 and the accuracy was 0.830 in distinguishing MCI and DM. Conclusion: The SVM model based on MRI radiomics exhibits high efficacy in the diagnosis of cognitive dysfunction and evaluation of its severity among patients with T2DM.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".