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Record W4407397928 · doi:10.1016/j.isci.2025.112019

Exploring ultraweak photon emissions as optical markers of brain activity

2025· article· en· W4407397928 on OpenAlexafffund
H Casey, Isabella DiBerardino, Mattia Bonzanni, Nicolas Rouleau, Nirosha J. Murugan

Bibliographic record

VenueiScience · 2025
Typearticle
Languageen
FieldMedicine
TopicBiofield Effects and Biophysics
Canadian institutionsWilfrid Laurier UniversityAlgoma University
FundersSocial Sciences and Humanities Research CouncilNatural Sciences and Engineering Research Council of CanadaOptica Foundation
KeywordsTwo-photon excitation microscopyPhotonChemistryNeurosciencePhysicsBiophysicsNanotechnologyOpticsPsychologyMaterials scienceBiology

Abstract

fetched live from OpenAlex

Brains are highly metabolic organs that emit ultraweak photon emissions (UPEs), which predict oxidative stress, aging, and neurodegeneration. UPEs are triggered by neurotransmitters and biophysical stimuli, but they are also generated by cells at rest and can be passively recorded using modern photodetectors in dark environments. UPEs play a role in cell-to-cell communication, and neural cells might even have waveguiding properties that support optical channels. However, it remains uncertain whether passive light emissions can be used to infer brain states as electric and magnetic fields do for encephalography. We present evidence that brain UPEs differ from background light in spectral and entropic properties, respond dynamically to tasks and stimulation, and correlate moderately with brain rhythms. We discuss these findings in the context of other neuroimaging methods, the potential of new measurement parameters, the limitations of light-based readouts, and the possibility of developing a platform to readout functional brain states: photoencephalography.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.005

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0000.000
Scholarly communication0.0000.001
Open science0.0000.001
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.045
GPT teacher head0.314
Teacher spread0.269 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations18
Published2025
Admission routes2
Has abstractyes

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